BNIPL and RECQL5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BNIPL	RECQL5
Description		BCL2 interacting protein like	RecQ like helicase 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Cytosol Transcription Preinitiation Complex
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding 3'-5' DNA Helicase Activity Metal Ion Binding Catalytic Activity, Acting On DNA
	Biological Process	Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Growth Rate	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Repair DNA Recombination Regulation Of DNA-templated Transcription DNA Damage Response Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Division Chromosome Separation Cellular Response To Xenobiotic Stimulus Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic DNA-templated DNA Replication Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronic kidney disease ( 20383146) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Type 2 diabetes ( 30297969)	Appendicular lean mass ( 33097823) Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)
Interacting Genes		13 interacting genes: ARHGAP1 BCL2 BCL2L1 BNIP2 FKBP8 GFER MIF NME2 PXDN PYCR1 RECQL5 RHOU SNAPIN	21 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PCNA PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B
Entrez ID		149428	9400
HPRD ID		16557	04806
Ensembl ID		ENSG00000163141	ENSG00000108469
Uniprot IDs		Q7Z465	B3KQK2 O94762
PDB IDs			4BK0 5LB3 5LB5 5LB8 5LBA 7ZML 7ZMM 7ZMN 7ZMO 7ZMP 7ZMQ 7ZMR 7ZMS 7ZMT 7ZMV 8RL5 8RL6 8RL9 8RLA 9EI1 9EI2 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		Dendritic Cell Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of B Cell Apoptotic Process Protein Homotrimerization Regulation Of Signal Transduction Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Trimerization Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Anoikis Regulation Of B Cell Apoptotic Process Cytosol Negative Regulation Of Myeloid Cell Apoptotic Process Identical Protein Binding Programmed Cell Death Involved In Cell Development Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Apoptotic Signaling Pathway Isomerase Activity Regulation Of Anoikis Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Intracellular Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Leukocyte Proliferation Sensory Organ Development Regulation Of Myeloid Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Lymphocyte Apoptotic Process Cellular Response To Alkaloid Pigment Granule Organization Channel Activity Regulation Of Cellular Localization Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Recombinational Repair Chromosome Organization Double-strand Break Repair Via Homologous Recombination DNA Recombination Telomere Maintenance DNA Repair DNA Strand Elongation Double-strand Break Repair Chromosomal Region Telomeric 3' Overhang Formation Telomere Organization Mre11 Complex BRCA1-C Complex Replication Fork Chromosome, Telomeric Region DNA Metabolic Process Homologous Recombination R-loop Processing DNA Damage Response Regulation Of DNA Repair Meiotic Cell Cycle Mitotic G2/M Transition Checkpoint DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Double-strand Break Processing Negative Regulation Of Mitotic Cell Cycle Reciprocal Meiotic Recombination Cellular Response To Stress Site Of Double-strand Break DNA Damage Checkpoint Signaling Nucleus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity PML Body Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Replication Fork Processing Negative Regulation Of Cell Cycle Process Negative Regulation Of DNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair
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