BNIPL and FKBP8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		BNIPL	FKBP8
Description		BCL2 interacting protein like	FKBP prolyl isomerase 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Mitochondrial Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane Mitochondrial Membrane Protein-containing Complex
	Molecular Function	Protein Binding Identical Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Calmodulin Binding Isomerase Activity Identical Protein Binding Protein Folding Chaperone Metal Ion Binding Disordered Domain Specific Binding
	Biological Process	Apoptotic Process Negative Regulation Of Cell Population Proliferation Regulation Of Growth Rate	Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Signal Transduction Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Regulation Of Gene Expression Dorsal/ventral Neural Tube Patterning Neural Tube Development BMP Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process Neuron Fate Specification Regulation Of Macromolecule Metabolic Process Protein Localization To Mitochondrion Regulation Of Mitophagy
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronic kidney disease ( 20383146) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Type 2 diabetes ( 30297969)	Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)
Interacting Genes		13 interacting genes: ARHGAP1 BCL2 BCL2L1 BNIP2 FKBP8 GFER MIF NME2 PXDN PYCR1 RECQL5 RHOU SNAPIN	52 interacting genes: AQP6 ARHGEF5 ARL13B ATP13A2 BCL2 BCL2L1 BIK BNIPL CD79A CIDEB CLCN1 CXCR2 CYB561 CYBRD1 EBP EGFR ELOVL4 ERBB2 ERGIC3 FAM174A FGF14 GPR37 JAGN1 MAPK14 MTOR OGT PEX12 PLN PPP3CA PSMC1 PSMD2 RETREG3 RHBDD2 RHEB SCN3B SHANK3 SLC10A1 SLC10A6 SLC35A5 SLC35B1 SLC71A2 SMO TERF1 TMEM14B TMEM254 TMEM31 TMEM43 TMEM45B TMEM80 TMX1 VHL ZFPL1
Entrez ID		149428	23770
HPRD ID		16557	05327
Ensembl ID		ENSG00000163141	ENSG00000105701
Uniprot IDs		Q7Z465	B2R8G6 Q14318
PDB IDs			2AWG 2D9F 2F2D 2MF9 3EY6 5MGX
Enriched GO Terms of Interacting Partners?		Dendritic Cell Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway BH3 Domain Binding Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of B Cell Apoptotic Process Protein Homotrimerization Regulation Of Signal Transduction Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Trimerization Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Anoikis Regulation Of B Cell Apoptotic Process Cytosol Negative Regulation Of Myeloid Cell Apoptotic Process Identical Protein Binding Programmed Cell Death Involved In Cell Development Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Apoptotic Signaling Pathway Isomerase Activity Regulation Of Anoikis Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Intracellular Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Leukocyte Proliferation Sensory Organ Development Regulation Of Myeloid Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Lymphocyte Apoptotic Process Cellular Response To Alkaloid Pigment Granule Organization Channel Activity Regulation Of Cellular Localization Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of Cellular Localization Mitochondrial Membrane Negative Regulation Of Catabolic Process Regulation Of Protein Localization Bcl-2 Family Protein Complex Protein Binding Transmembrane Transport Negative Regulation Of Autophagy Dendritic Cell Apoptotic Process Ascorbate Homeostasis Intracellular Signal Transduction Regulation Of Membrane Potential Transmembrane Monodehydroascorbate Reductase Activity Striated Muscle Cell Development Skeletal Muscle Fiber Development Bile Acid:sodium Symporter Activity Positive Regulation Of Growth Regulation Of Protein Catabolic Process BH3 Domain Binding Myotube Cell Development Regulation Of Establishment Of Protein Localization Muscle Cell Development Negative Regulation Of Calcium Ion Transmembrane Transport Intracellular Signaling Cassette Regulation Of TORC1 Signaling Channel Activity ERBB2-EGFR Signaling Pathway Cell Morphogenesis Autophagy Negative Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of Striated Muscle Cell Differentiation Oligodendrocyte Differentiation Monoatomic Ion Transport Regulation Of Myotube Differentiation Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Translational Initiation Pyrimidine Nucleotide-sugar Transmembrane Transport Regulation Of Growth Positive Regulation Of Translational Initiation Mononuclear Cell Proliferation Nucleotide-sugar Transmembrane Transport Negative Regulation Of Calcium Ion Transport Identical Protein Binding Proteasomal Protein Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Proteasome Regulatory Particle Ciliary Membrane
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