IL23R and STAT3

Number of citations of the paper that reports this interaction (PMID 12023369)
206

Data Source:
HPRD (in vivo, in vitro)

		IL23R	STAT3
Gene Name		interleukin 23 receptor	signal transducer and activator of transcription 3 (acute-phase response factor)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Receptor Complex Interleukin-23 Receptor Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane
	Molecular Function	Interleukin-12 Receptor Binding Interleukin-23 Binding Interleukin-23 Receptor Activity	RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding CCR5 Chemokine Receptor Binding Glucocorticoid Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Positive Regulation Of Activation Of JAK2 Kinase Activity Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Response To Interferon-gamma Interleukin-23-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Negative Regulation Of Transcription From RNA Polymerase II Promoter Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Import Into Nucleus Movement Of Cell Or Subcellular Component Acute-phase Response Signal Transduction JAK-STAT Cascade Nervous System Development Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Intracellular Receptor Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Somatic Stem Cell Maintenance Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Eating Behavior Response To Ethanol Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Astrocyte Differentiation Radial Glial Cell Differentiation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of Cell Death Interleukin-6-mediated Signaling Pathway Negative Regulation Of Neuron Migration
Pathways			Signaling by PDGF Signalling by NGF Signaling by FGFR in disease Cellular Senescence Interleukin-6 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by SCF-KIT Signaling by Interleukins Transcriptional regulation of pluripotent stem cells Downstream signal transduction Signaling by FGFR1 mutants Signalling to STAT3 Signaling by FGFR mutants Signaling by FGFR1 fusion mutants POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by Leptin Growth hormone receptor signaling
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469 20062062) Behcet's disease ( 20622878 20622879) Crohn's disease ( 18587394 20570966 22936669 22412388 17435756 17554300 21102463 17447842 22293688 17804789) Inflammatory bowel disease ( 18758464 23128233 17068223) Leprosy ( 22019778) Psoriasis ( 20953190 19169254) Ulcerative colitis ( 19915572 20228799 21297633 19122664)	Crohn's disease ( 18587394 21102463 23266558) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 21833088 20159113)
Protein-Protein Interactions		5 interactors: C1D IL12RB1 IL23A JAK2 STAT3	161 interactors: ADRB2 AMBP AR ARFIP2 ASXL1 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 CAPN1 CAPNS1 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBB2IP FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GATA1 GATA2 GHR GNB2L1 GNL3 GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HIC1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KPNA1 KPNA6 LAMB2 LCK LEP LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MET MORC4 MRPS31 MTOR MYOD1 NCOA1 NDUFA13 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 OGDHL PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PML PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RAC1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 SCAF11 SETD7 SIAH1 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 SSSCA1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TRIM28 TRIP10 TSHR TSLP ZFPM2 ZNF148 ZNF467
Entrez ID		149233	6774
HPRD ID		16249	00026
Ensembl ID		ENSG00000162594	ENSG00000168610
Uniprot IDs		Q5VWK5	K7ENL3 P40763
PDB IDs
Enriched GO Terms of Interacting Partners?		Interleukin-12-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Response To Interleukin-12 Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of T-helper Cell Differentiation Regulation Of Defense Response To Virus By Host Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Response To Growth Hormone Positive Regulation Of Cytokine Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Interferon-gamma Production JAK-STAT Cascade Defense Response Positive Regulation Of Tumor Necrosis Factor Production Cytokine-mediated Signaling Pathway Positive Regulation Of JAK-STAT Cascade Regulation Of Cell Proliferation Regulation Of Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Interferon-gamma Production Regulation Of T Cell Mediated Cytotoxicity Cellular Response To Cytokine Stimulus Regulation Of JAK-STAT Cascade Regulation Of Cell Migration	Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Defense Response Response To Cytokine Regulation Of Signal Transduction Immune System Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Communication Signaling Positive Regulation Of Gene Expression Response To Stress Response To Stimulus Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Regulation Of Immune Response Immune Response Protein Autophosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Positive Regulation Of Cell Proliferation Positive Regulation Of Immune System Process Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Response To External Stimulus Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation
Tagcloud ?		1p36 21q21 bowel c13orf31 colitis crohn danish epistasis epistatic il10 latvia latvian lithuania lithuanian maps mst1 nkx2 northeastern ormdl3 ptpn22 rs2476601 rs3764147 snp snps strongest subphenotype tagging uc ulcerative	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Difference) ?		1p36 21q21 bowel c13orf31 colitis crohn danish epistasis epistatic il10 latvia latvian lithuania lithuanian maps mst1 nkx2 northeastern ormdl3 ptpn22 rs2476601 rs3764147 snp snps strongest subphenotype tagging uc ulcerative	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Intersection) ?