IL23R and C1D

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		IL23R	C1D
Gene Name		interleukin 23 receptor	C1D nuclear receptor corepressor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Receptor Complex Interleukin-23 Receptor Complex	Nuclear Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Transcriptional Repressor Complex
	Molecular Function	Interleukin-12 Receptor Binding Interleukin-23 Binding Interleukin-23 Receptor Activity	DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding Ligand-dependent Nuclear Receptor Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Positive Regulation Of Activation Of JAK2 Kinase Activity Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Response To Interferon-gamma Interleukin-23-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Maturation Of 5.8S RRNA Transcription, DNA-templated Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469 20062062) Behcet's disease ( 20622878 20622879) Crohn's disease ( 18587394 20570966 22936669 22412388 17435756 17554300 21102463 17447842 22293688 17804789) Inflammatory bowel disease ( 18758464 23128233 17068223) Leprosy ( 22019778) Psoriasis ( 20953190 19169254) Ulcerative colitis ( 19915572 20228799 21297633 19122664)
Protein-Protein Interactions		5 interactors: C1D IL12RB1 IL23A JAK2 STAT3	10 interactors: APP IL23R NCOR1 NCOR2 NR1D1 PCBD2 PRKDC THRA THRB TSNAX
Entrez ID		149233	10438
HPRD ID		16249	07382
Ensembl ID		ENSG00000162594
Uniprot IDs		Q5VWK5	Q13901
PDB IDs
Enriched GO Terms of Interacting Partners?		Interleukin-12-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Response To Interleukin-12 Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of T-helper Cell Differentiation Regulation Of Defense Response To Virus By Host Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Response To Growth Hormone Positive Regulation Of Cytokine Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Interferon-gamma Production JAK-STAT Cascade Defense Response Positive Regulation Of Tumor Necrosis Factor Production Cytokine-mediated Signaling Pathway Positive Regulation Of JAK-STAT Cascade Regulation Of Cell Proliferation Regulation Of Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Interferon-gamma Production Regulation Of T Cell Mediated Cytotoxicity Cellular Response To Cytokine Stimulus Regulation Of JAK-STAT Cascade Regulation Of Cell Migration	Transcription Initiation From RNA Polymerase II Promoter Type I Pneumocyte Differentiation DNA-templated Transcription, Initiation Mating Behavior Female Courtship Behavior Positive Regulation Of Cellular Metabolic Process Mating Intracellular Receptor Signaling Pathway Lung Epithelial Cell Differentiation Reproduction Lung Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Lung Epithelium Development Regulation Of Female Receptivity Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Reproductive Process Positive Regulation Of Transcription, DNA-templated Rhythmic Process Female Mating Behavior Regulation Of Nitrogen Compound Metabolic Process Cell Differentiation Homeostatic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Multicellular Organism Reproduction Positive Regulation Of Gene Expression Response To Lipid Response To Organic Substance Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Response To Hormone Hormone-mediated Signaling Pathway Notch Signaling Pathway Response To Steroid Hormone Regulation Of Cellular Ketone Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Steroid Hormone Stimulus
Tagcloud ?		1p36 21q21 bowel c13orf31 colitis crohn danish epistasis epistatic il10 latvia latvian lithuania lithuanian maps mst1 nkx2 northeastern ormdl3 ptpn22 rs2476601 rs3764147 snp snps strongest subphenotype tagging uc ulcerative	1day acuvue asymptomatic avte cc clariti comfort dailies disposables dryness dt1 eod habitual hours hydrogel lenses lsm masked metric ocular ratings shdds silicone symptomatic total1 trueye wearers wearing wore
Tagcloud (Difference) ?		1p36 21q21 bowel c13orf31 colitis crohn danish epistasis epistatic il10 latvia latvian lithuania lithuanian maps mst1 nkx2 northeastern ormdl3 ptpn22 rs2476601 rs3764147 snp snps strongest subphenotype tagging uc ulcerative	1day acuvue asymptomatic avte cc clariti comfort dailies disposables dryness dt1 eod habitual hours hydrogel lenses lsm masked metric ocular ratings shdds silicone symptomatic total1 trueye wearers wearing wore
Tagcloud (Intersection) ?