IL23R and IL12RB1

Number of citations of the paper that reports this interaction (PMID 12023369)
206

Data Source:
HPRD (in vitro, in vivo)

		IL23R	IL12RB1
Gene Name		interleukin 23 receptor	interleukin 12 receptor, beta 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Receptor Complex Interleukin-23 Receptor Complex	External Side Of Plasma Membrane Interleukin-12 Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Interleukin-12 Receptor Binding Interleukin-23 Binding Interleukin-23 Receptor Activity	Cytokine Receptor Activity Interleukin-12 Receptor Binding Interleukin-12 Receptor Activity Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Positive Regulation Of Activation Of JAK2 Kinase Activity Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Response To Interferon-gamma Interleukin-23-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469 20062062) Behcet's disease ( 20622878 20622879) Crohn's disease ( 18587394 20570966 22936669 22412388 17435756 17554300 21102463 17447842 22293688 17804789) Inflammatory bowel disease ( 18758464 23128233 17068223) Leprosy ( 22019778) Psoriasis ( 20953190 19169254) Ulcerative colitis ( 19915572 20228799 21297633 19122664)	Pulmonary function in asthmatics ( 23541324)
Protein-Protein Interactions		5 interactors: C1D IL12RB1 IL23A JAK2 STAT3	6 interactors: IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4
Entrez ID		149233	3594
HPRD ID		16249	03363
Ensembl ID		ENSG00000162594	ENSG00000096996
Uniprot IDs		Q5VWK5	P42701
PDB IDs
Enriched GO Terms of Interacting Partners?		Interleukin-12-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Response To Interleukin-12 Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Growth Hormone Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of T-helper Cell Differentiation Regulation Of Defense Response To Virus By Host Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Response To Growth Hormone Positive Regulation Of Cytokine Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Interferon-gamma Production JAK-STAT Cascade Defense Response Positive Regulation Of Tumor Necrosis Factor Production Cytokine-mediated Signaling Pathway Positive Regulation Of JAK-STAT Cascade Regulation Of Cell Proliferation Regulation Of Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Interferon-gamma Production Regulation Of T Cell Mediated Cytotoxicity Cellular Response To Cytokine Stimulus Regulation Of JAK-STAT Cascade Regulation Of Cell Migration	Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of NK T Cell Activation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Interferon-gamma Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Memory T Cell Differentiation Positive Regulation Of Interleukin-17 Production Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Interferon-gamma Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Interleukin-10 Production Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of T-helper Cell Differentiation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Defense Response To Virus By Host Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Defense Response To Gram-negative Bacterium Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of JAK-STAT Cascade Regulation Of Interleukin-12 Production Regulation Of Osteoclast Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cytokine Production Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of JAK-STAT Cascade
Tagcloud ?		1p36 21q21 bowel c13orf31 colitis crohn danish epistasis epistatic il10 latvia latvian lithuania lithuanian maps mst1 nkx2 northeastern ormdl3 ptpn22 rs2476601 rs3764147 snp snps strongest subphenotype tagging uc ulcerative	allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly
Tagcloud (Difference) ?		1p36 21q21 bowel c13orf31 colitis crohn danish epistasis epistatic il10 latvia latvian lithuania lithuanian maps mst1 nkx2 northeastern ormdl3 ptpn22 rs2476601 rs3764147 snp snps strongest subphenotype tagging uc ulcerative	allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly
Tagcloud (Intersection) ?