IL23R

Description		interleukin 23 receptor
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Prolactin Receptor Activity Interleukin-12 Receptor Binding Protein Binding Peptide Hormone Binding Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Response To Type II Interferon Interleukin-23-mediated Signaling Pathway Prolactin Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs
Diseases		Crohn's disease
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 21743469 23749187 20062062) Behcet's disease ( 33393726 20622879 20622878) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23850713 28067908 22936669 30500874 32581322 22412388 22293688 17447842 17435756 21102463 17554300 20570966 17804789 18587394) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233 28067908 18758464 28008999) Inflammatory skin disease ( 25574825) Leprosy ( 22019778 25642632) Pediatric autoimmune diseases ( 26301688) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Psoriasis ( 25903422 20953190 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Sarcoidosis ( 26051272 32826979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 19122664 19915572 28067908 20228799 26398853 32072174 21297633) Vogt-Koyanagi-Harada syndrome ( 25108386)
Interacting Genes		5 interacting genes: C1D IL12RB1 IL23A JAK2 STAT3
Entrez ID		149233
HPRD ID		16249
Ensembl ID		ENSG00000162594
Uniprot IDs		Q5VWK5
PDB IDs		5MZV 6WDQ 8OE4
Enriched GO Terms of Interacting Partners?		Interleukin-23-mediated Signaling Pathway Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of T-helper 17 Type Immune Response Interleukin-12 Receptor Complex Positive Regulation Of Skeletal Muscle Cell Proliferation Interleukin-23 Receptor Complex Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Type II Interferon Production Interleukin-12 Receptor Binding Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of T Cell Proliferation Interleukin-12-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of NK T Cell Activation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Type II Interferon Production Positive Regulation Of Cytokine Production Regulation Of Memory T Cell Differentiation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Adaptive Immune Response Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Cell Fate Commitment Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Skeletal Muscle Cell Proliferation T-helper 1 Cell Differentiation Interleukin-6-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation Positive Regulation Of T-helper 1 Type Immune Response Regulation Of Tumor Necrosis Factor Production Regulation Of T Cell Proliferation Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Growth Hormone Receptor Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Adaptive Immune Response Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Positive Regulation Of Interleukin-17 Production
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