IL12RB1 and IL23A

Number of citations of the paper that reports this interaction (PubMedID 12023369)
0

Data Source:
HPRD (in vivo)

		IL12RB1	IL23A
Description		interleukin 12 receptor subunit beta 1	interleukin 23 subunit alpha
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Interleukin-23 Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Coreceptor Activity Interleukin-12 Receptor Activity Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity	Cytokine Activity Protein Binding Interleukin-23 Receptor Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation T-helper 1 Cell Differentiation Cellular Response To Type II Interferon Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Activation Tissue Remodeling Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of NK T Cell Proliferation Defense Response To Virus Regulation Of Primary Metabolic Process Positive Regulation Of Neutrophil Chemotaxis Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Leukocyte Differentiation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs			Briakinumab Ustekinumab Guselkumab Tildrakizumab Risankizumab
Diseases		IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Mental health study participation (completed survey) ( 31263887) Pulmonary function in asthmatics ( 23541324) Systemic sclerosis ( 30572963 31672989) Waist circumference adjusted for body mass index ( 34021172)	Axial length ( 24144296) Psoriasis ( 19169254 20953190 23143594 25574825 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: CFTR IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4	3 interacting genes: IL12RB1 IL23R PEX19
Entrez ID		3594	51561
HPRD ID		03363	12026
Ensembl ID		ENSG00000096996	ENSG00000110944
Uniprot IDs		P42701	Q9NPF7
PDB IDs		6WDP 6WDQ 8C7M 8ODX 8OE4 8XRP 8YI7	3D85 3D87 3DUH 3QWR 4GRW 5MJ3 5MJ4 5MXA 5MZV 5NJD 6UIB 6WDQ 8CR8 8OE4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Cell Fate Commitment Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Regulation Of T-helper 17 Type Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Interleukin-12-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Regulation Of T-helper Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Memory T Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production T-helper 1 Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Interleukin-10 Production Regulation Of Type II Interferon Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of T Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Alpha-beta T Cell Activation Interleukin-23 Receptor Binding Interleukin-23 Complex Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T Cell Mediated Cytotoxicity T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of Natural Killer Cell Activation Positive Regulation Of Interleukin-12 Production T Cell Differentiation Involved In Immune Response Regulation Of Defense Response To Virus By Host Regulation Of T Cell Mediated Cytotoxicity	Interleukin-23 Binding Interleukin-23 Receptor Activity Interleukin-23 Receptor Complex Interleukin-12 Receptor Binding Interleukin-23-mediated Signaling Pathway Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Memory T Cell Differentiation Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Cell Fate Commitment Positive Regulation Of T-helper 1 Type Immune Response Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T-helper 17 Type Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Activated T Cell Proliferation Cytokine Binding Regulation Of Defense Response To Virus By Host Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cytokine Receptor Activity Regulation Of T-helper Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of Defense Response To Virus Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Leukocyte Mediated Cytotoxicity Response To Type II Interferon Regulation Of T Cell Mediated Immunity Positive Regulation Of T Cell Proliferation Interleukin-12 Receptor Activity Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Regulation Of Type II Interferon Production Positive Regulation Of T Cell Differentiation Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Differentiation
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