IL12RB1

Gene Name		interleukin 12 receptor, beta 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	External Side Of Plasma Membrane Interleukin-12 Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Interleukin-12 Receptor Activity Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways
Drugs
Diseases
GWAS		Pulmonary function in asthmatics ( 23541324)
Protein-protein Interactions		6 interactors: IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4
Entrez ID		3594
HPRD ID		03363
Ensembl ID		ENSG00000096996
Uniprot IDs		P42701
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of NK T Cell Activation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Interferon-gamma Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Memory T Cell Differentiation Positive Regulation Of Interleukin-17 Production Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Interferon-gamma Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Interleukin-10 Production Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of T-helper Cell Differentiation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Defense Response To Virus By Host Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Defense Response To Gram-negative Bacterium Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of JAK-STAT Cascade Regulation Of Interleukin-12 Production Regulation Of Osteoclast Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cytokine Production Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of JAK-STAT Cascade
Tagcloud ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly