IL12RB1 and SNRPD3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IL12RB1	SNRPD3
Gene Name		interleukin 12 receptor, beta 1	small nuclear ribonucleoprotein D3 polypeptide 18kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	External Side Of Plasma Membrane Interleukin-12 Receptor Complex Interleukin-23 Receptor Complex	Nucleoplasm Spliceosomal Complex U7 SnRNP U1 SnRNP U4 SnRNP U12-type Spliceosomal Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex Methylosome PICln-Sm Protein Complex SMN-Sm Protein Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Interleukin-12 Receptor Activity Interleukin-23 Binding Interleukin-23 Receptor Activity	Protein Binding Enzyme Binding Poly(A) RNA Binding Histone Pre-mRNA DCP Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription Histone MRNA Metabolic Process RNA Splicing Gene Expression MRNA 3'-end Processing NcRNA Metabolic Process
Pathways			mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Metabolism of non-coding RNA mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Cleavage of Growing Transcript in the Termination Region SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs snRNP Assembly Processing of Capped Intronless Pre-mRNA SLBP independent Processing of Histone Pre-mRNAs RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Pulmonary function in asthmatics ( 23541324)
Protein-Protein Interactions		6 interactors: IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4	27 interactors: CASP8 CLNS1A CRY1 DDX20 GEMIN2 GEMIN5 GEMIN6 GEMIN7 IL12RB1 IL7R LSM3 LSM7 NR1I3 PRMT5 RBL1 SMN1 SMN2 SNRPB SNRPE SNRPG SNRPN SREK1 STRAP STXBP2 STXBP3 TRDMT1 WDR77
Entrez ID		3594	6634
HPRD ID		03363	03039
Ensembl ID		ENSG00000096996
Uniprot IDs		P42701	B4DJP7 P62318
PDB IDs			1D3B 2Y9A 2Y9B 2Y9C 2Y9D 3CW1 3PGW 3VRI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of NK T Cell Activation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Interferon-gamma Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Memory T Cell Differentiation Positive Regulation Of Interleukin-17 Production Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Interferon-gamma Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Interleukin-10 Production Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of T-helper Cell Differentiation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Defense Response To Virus By Host Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Defense Response To Gram-negative Bacterium Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of JAK-STAT Cascade Regulation Of Interleukin-12 Production Regulation Of Osteoclast Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cytokine Production Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of JAK-STAT Cascade	Spliceosomal SnRNP Assembly RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing Ribonucleoprotein Complex Assembly RNA Processing MRNA Metabolic Process Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Cellular Macromolecular Complex Assembly RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Component Assembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Spliceosomal Complex Assembly Nitrogen Compound Metabolic Process Cellular Metabolic Process Histone MRNA Metabolic Process Termination Of RNA Polymerase II Transcription Neutrophil Degranulation Neutrophil Activation Involved In Immune Response DNA-templated Transcription, Termination MRNA 3'-end Processing RNA 3'-end Processing Response To Organic Substance Neutrophil Mediated Immunity Neutrophil Activation Cellular Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Metabolic Process Cell Activation Leukocyte Degranulation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulated Secretory Pathway Vesicle Docking Involved In Exocytosis Leukocyte Activation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Negative Regulation Of Glucocorticoid Secretion Blue Light Signaling Pathway
Tagcloud ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly
Tagcloud (Difference) ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly
Tagcloud (Intersection) ?