IL12RB1 and IL12RB2

Number of citations of the paper that reports this interaction (PMID 8943050)
84

Data Source:
HPRD (in vitro, in vivo)

		IL12RB1	IL12RB2
Gene Name		interleukin 12 receptor, beta 1	interleukin 12 receptor, beta 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	External Side Of Plasma Membrane Interleukin-12 Receptor Complex Interleukin-23 Receptor Complex	Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Interleukin-12 Receptor Activity Interleukin-23 Binding Interleukin-23 Receptor Activity	Cytokine Receptor Activity Protein Kinase Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Interferon-gamma Production Positive Regulation Of Interferon-gamma Production
Pathways
Drugs
Diseases
GWAS		Pulmonary function in asthmatics ( 23541324)	Behcet's disease ( 20622878 20622879) Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233) Primary biliary cirrhosis ( 19458352 21399635 20639880)
Protein-Protein Interactions		6 interactors: IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4	5 interactors: IL12B IL12RB1 JAK2 SOCS3 STAT4
Entrez ID		3594	3595
HPRD ID		03363	03383
Ensembl ID		ENSG00000096996	ENSG00000081985
Uniprot IDs		P42701	B4DGA4 Q99665
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of NK T Cell Activation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Interferon-gamma Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Memory T Cell Differentiation Positive Regulation Of Interleukin-17 Production Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Interferon-gamma Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Interleukin-10 Production Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of T-helper Cell Differentiation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Defense Response To Virus By Host Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of T-helper Cell Differentiation Defense Response To Gram-negative Bacterium Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of JAK-STAT Cascade Regulation Of Interleukin-12 Production Regulation Of Osteoclast Differentiation Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cytokine Production Regulation Of Defense Response To Virus Positive Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Regulation Of JAK-STAT Cascade	Cytokine-mediated Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Cytokine Stimulus Response To Interferon-gamma Response To Cytokine Interleukin-12-mediated Signaling Pathway JAK-STAT Cascade Positive Regulation Of T-helper 17 Cell Lineage Commitment Response To Interleukin-12 Positive Regulation Of Memory T Cell Differentiation Regulation Of JAK-STAT Cascade Positive Regulation Of T-helper 17 Type Immune Response Regulation Of Memory T Cell Differentiation Positive Regulation Of T-helper 1 Type Immune Response Cellular Response To Organic Substance Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cell Fate Commitment Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Innate Immune Response Regulation Of Interferon-gamma-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Regulation Of Immune Response Growth Hormone Receptor Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Growth Hormone Stimulus Positive Regulation Of T-helper Cell Differentiation Response To Organic Substance Regulation Of Defense Response To Virus By Host Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Inflammatory Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Cell Activation Regulation Of T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Response To Growth Hormone Positive Regulation Of Cytokine Production Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process
Tagcloud ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		allelic candidiasis cybb definition designation errors ifngr1 ifngr2 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?