VEGFA and SEMA3F

Number of citations of the paper that reports this interaction (PMID 12845630)
22

Data Source:
HPRD (in vivo, in vitro)

		VEGFA	SEMA3F
Gene Name		vascular endothelial growth factor A	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Cell Surface Membrane Secretory Granule Platelet Alpha Granule Lumen	Extracellular Space Membrane
	Molecular Function	Fibronectin Binding Cytokine Activity Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Neuropilin Binding Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 1 Binding Vascular Endothelial Growth Factor Receptor 2 Binding Protein Heterodimerization Activity Receptor Agonist Activity Extracellular Matrix Binding	Receptor Activity Chemorepellent Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Ovarian Follicle Development Patterning Of Blood Vessels Vasculogenesis Response To Hypoxia In Utero Embryonic Development Kidney Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Receptor Internalization Basophil Chemotaxis Platelet Degranulation Positive Regulation Of Leukocyte Migration Heart Morphogenesis Outflow Tract Morphogenesis Coronary Vein Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Mesoderm Development Lactation Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Platelet Activation Monocyte Differentiation Macrophage Differentiation Lung Development Positive Regulation Of Cell Migration Regulation Of CGMP Metabolic Process Epithelial Cell Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Post-embryonic Camera-type Eye Development Positive Regulation Of Protein Complex Assembly Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Tube Formation Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Lymph Vessel Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Growth Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Surfactant Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Camera-type Eye Morphogenesis Cardiac Muscle Fiber Development Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cellular Component Movement Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Primitive Erythrocyte Differentiation Mammary Gland Alveolus Development Positive Regulation Of Mast Cell Chemotaxis Cardiac Vascular Smooth Muscle Cell Development Coronary Artery Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Kinase D Signaling	Axon Guidance Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Ventral Trunk Neural Crest Cell Migration Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways		VEGF binds to VEGFR leading to receptor dimerization Cellular response to hypoxia VEGF ligand-receptor interactions Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by VEGF Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Regulation of gene expression by Hypoxia-inducible Factor
Drugs		Bevacizumab Minocycline Gliclazide Carvedilol Ranibizumab Pyroglutamic Acid Tris(Hydroxymethyl)Aminomethane Vandetanib Dalteparin Aflibercept
Diseases
GWAS		Adiponectin levels ( 22479202) Age-related macular degeneration ( 23455636 21665990) Chronic kidney disease ( 20383146) Coronary heart disease ( 22319020) Thyroid hormone levels ( 23408906) Type 2 diabetes ( 18372903) Urate levels ( 23263486) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		25 interactors: ADAMTS1 AKT1 CRYAB CTGF ELAVL1 EPHB2 FLT1 GPC1 HNRNPD IGFBP7 KDR LYVE1 NRP1 NRP2 PGF PRRG4 SEMA3F SPARC TNXB U2AF1 VEGFB VPS35 VTN YBX1 YBX3	6 interactors: NRP1 NRP2 SHBG SLC35G2 UBA1 VEGFA
Entrez ID		7422	6405
HPRD ID		01889	03079
Ensembl ID		ENSG00000112715	ENSG00000001617
Uniprot IDs		A2A2V4 P15692	Q13275
PDB IDs		1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS
Enriched GO Terms of Interacting Partners?		Regulation Of Endothelial Cell Proliferation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Proliferation Cardiovascular System Development Angiogenesis Positive Regulation Of Cell Migration Blood Vessel Development Positive Regulation Of Cell Motility Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cellular Component Movement Vasculature Development Positive Regulation Of Locomotion Multicellular Organismal Development Anatomical Structure Formation Involved In Morphogenesis Developmental Process Positive Regulation Of Endothelial Cell Migration Anatomical Structure Development Blood Vessel Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Anatomical Structure Morphogenesis Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Ventral Trunk Neural Crest Cell Migration Regulation Of Cellular Component Movement Positive Regulation Of Epithelial Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Axon Extension Involved In Axon Guidance Regulation Of Endothelial Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Proliferation Regulation Of Cell Migration Embryo Development Sympathetic Ganglion Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Motility Facial Nerve Structural Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Facial Nerve Morphogenesis Organ Development Regulation Of MRNA Stability System Development Cranial Nerve Development Regulation Of RNA Stability Sprouting Angiogenesis	Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vestibulocochlear Nerve Structural Organization Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Ganglion Morphogenesis Sensory Neuron Axon Guidance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Endothelial Cell Proliferation Regulation Of Retinal Ganglion Cell Axon Guidance Facioacoustic Ganglion Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Positive Regulation Of Epithelial Cell Migration Developmental Cell Growth Coronary Artery Morphogenesis Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Ventral Trunk Neural Crest Cell Migration Regulation Of Endothelial Cell Proliferation Vascular Endothelial Growth Factor Receptor Signaling Pathway Hypothalamus Cell Migration Neural Crest Cell Migration Involved In Autonomic Nervous System Development Trigeminal Ganglion Development Endothelial Cell Chemotaxis Positive Regulation Of Axon Extension Involved In Axon Guidance Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Regulation Of Endothelial Cell Migration Growth Hypothalamus Cell Differentiation Vestibulocochlear Nerve Development Axon Extension Involved In Axon Guidance Sympathetic Ganglion Development Coronary Vasculature Morphogenesis Facial Nerve Structural Organization Facial Nerve Morphogenesis Regulation Of Epithelial Cell Migration Cell Growth Cerebral Cortex Tangential Migration Positive Regulation Of Epithelial Cell Proliferation Commissural Neuron Axon Guidance Coronary Vasculature Development Ganglion Development Ameboidal-type Cell Migration Regulation Of Axon Extension Involved In Axon Guidance Parasympathetic Nervous System Development Anatomical Structure Arrangement Cell Migration Involved In Sprouting Angiogenesis Sympathetic Nervous System Development Hypothalamus Development Positive Chemotaxis
Tagcloud ?		autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups wiley
Tagcloud (Difference) ?		autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups wiley
Tagcloud (Intersection) ?