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VEGFA and PRRG4
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
VEGFA
PRRG4
Gene Name
vascular endothelial growth factor A
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Proteinaceous Extracellular Matrix
Extracellular Space
Cytoplasm
Cell Surface
Membrane
Secretory Granule
Platelet Alpha Granule Lumen
Extracellular Region
Integral Component Of Membrane
Molecular Function
Fibronectin Binding
Cytokine Activity
Platelet-derived Growth Factor Receptor Binding
Vascular Endothelial Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Heparin Binding
Neuropilin Binding
Chemoattractant Activity
Identical Protein Binding
Protein Homodimerization Activity
Vascular Endothelial Growth Factor Receptor 1 Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Protein Heterodimerization Activity
Receptor Agonist Activity
Extracellular Matrix Binding
Molecular_function
Calcium Ion Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Angiogenesis
Ovarian Follicle Development
Patterning Of Blood Vessels
Vasculogenesis
Response To Hypoxia
In Utero Embryonic Development
Kidney Development
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Neuroblast Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Receptor Internalization
Basophil Chemotaxis
Platelet Degranulation
Positive Regulation Of Leukocyte Migration
Heart Morphogenesis
Outflow Tract Morphogenesis
Coronary Vein Morphogenesis
Regulation Of Transcription From RNA Polymerase II Promoter
Nervous System Development
Mesoderm Development
Lactation
Blood Coagulation
Positive Regulation Of Cell Proliferation
Regulation Of Cell Shape
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Platelet Activation
Monocyte Differentiation
Macrophage Differentiation
Lung Development
Positive Regulation Of Cell Migration
Regulation Of CGMP Metabolic Process
Epithelial Cell Differentiation
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Post-embryonic Camera-type Eye Development
Positive Regulation Of Protein Complex Assembly
Positive Regulation Of Protein Autophosphorylation
Activation Of Protein Kinase Activity
Positive Regulation Of CREB Transcription Factor Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Tube Formation
Endothelial Cell Chemotaxis
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Lymph Vessel Morphogenesis
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
VEGF-activated Neuropilin Signaling Pathway
Growth
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Positive Regulation Of Vascular Permeability
Surfactant Homeostasis
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell Maturation
Camera-type Eye Morphogenesis
Cardiac Muscle Fiber Development
Branching Morphogenesis Of An Epithelial Tube
Positive Regulation Of Axon Extension Involved In Axon Guidance
Artery Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Positive Regulation Of Positive Chemotaxis
Induction Of Positive Chemotaxis
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Cell Division
Positive Regulation Of Focal Adhesion Assembly
Primitive Erythrocyte Differentiation
Mammary Gland Alveolus Development
Positive Regulation Of Mast Cell Chemotaxis
Cardiac Vascular Smooth Muscle Cell Development
Coronary Artery Morphogenesis
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Hypoxia
Dopaminergic Neuron Differentiation
Commissural Neuron Axon Guidance
Positive Regulation Of Protein Kinase C Signaling
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Regulation Of Retinal Ganglion Cell Axon Guidance
Positive Regulation Of Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Histone Deacetylase Activity
Positive Regulation Of Retinal Ganglion Cell Axon Guidance
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Protein Kinase D Signaling
Biological_process
Pathways
VEGF binds to VEGFR leading to receptor dimerization
Cellular response to hypoxia
VEGF ligand-receptor interactions
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Signaling by VEGF
Response to elevated platelet cytosolic Ca2+
Platelet degranulation
Platelet activation, signaling and aggregation
Regulation of gene expression by Hypoxia-inducible Factor
Drugs
Bevacizumab
Minocycline
Gliclazide
Carvedilol
Ranibizumab
Pyroglutamic Acid
Tris(Hydroxymethyl)Aminomethane
Vandetanib
Dalteparin
Aflibercept
Diseases
GWAS
Adiponectin levels (
22479202
)
Age-related macular degeneration (
23455636
21665990
)
Chronic kidney disease (
20383146
)
Coronary heart disease (
22319020
)
Thyroid hormone levels (
23408906
)
Type 2 diabetes (
18372903
)
Urate levels (
23263486
)
Waist-hip ratio (
20935629
)
Parkinson's disease (age of onset) (
19772629
)
Protein-Protein Interactions
25 interactors:
ADAMTS1
AKT1
CRYAB
CTGF
ELAVL1
EPHB2
FLT1
GPC1
HNRNPD
IGFBP7
KDR
LYVE1
NRP1
NRP2
PGF
PRRG4
SEMA3F
SPARC
TNXB
U2AF1
VEGFB
VPS35
VTN
YBX1
YBX3
7 interactors:
AOC3
BCL10
HDAC1
HLA-C
RBBP8
UBE2K
VEGFA
Entrez ID
7422
79056
HPRD ID
01889
15187
Ensembl ID
ENSG00000112715
ENSG00000135378
Uniprot IDs
A2A2V4
P15692
Q9BZD6
PDB IDs
1BJ1
1CZ8
1FLT
1KAT
1KMX
1MJV
1MKG
1MKK
1QTY
1TZH
1TZI
1VGH
1VPF
1VPP
2FJG
2FJH
2QR0
2VGH
2VPF
3BDY
3P9W
3QTK
3S1B
3S1K
3V2A
4DEQ
4GLN
4GLS
Enriched GO Terms of Interacting Partners
?
Regulation Of Endothelial Cell Proliferation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Endothelial Cell Proliferation
Cardiovascular System Development
Angiogenesis
Positive Regulation Of Cell Migration
Blood Vessel Development
Positive Regulation Of Cell Motility
Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Cellular Component Movement
Vasculature Development
Positive Regulation Of Locomotion
Multicellular Organismal Development
Anatomical Structure Formation Involved In Morphogenesis
Developmental Process
Positive Regulation Of Endothelial Cell Migration
Anatomical Structure Development
Blood Vessel Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Epithelial Cell Proliferation
Regulation Of Locomotion
Anatomical Structure Morphogenesis
Sympathetic Neuron Projection Extension
Sympathetic Neuron Projection Guidance
Ventral Trunk Neural Crest Cell Migration
Regulation Of Cellular Component Movement
Positive Regulation Of Epithelial Cell Migration
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Neural Crest Cell Migration Involved In Autonomic Nervous System Development
Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance
Axon Extension Involved In Axon Guidance
Regulation Of Endothelial Cell Migration
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Proliferation
Regulation Of Cell Migration
Embryo Development
Sympathetic Ganglion Development
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cell Motility
Facial Nerve Structural Organization
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Facial Nerve Morphogenesis
Organ Development
Regulation Of MRNA Stability
System Development
Cranial Nerve Development
Regulation Of RNA Stability
Sprouting Angiogenesis
Response To Stress
Embryo Development
Positive Regulation Of Protein Kinase D Signaling
Basophil Chemotaxis
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Retinal Ganglion Cell Axon Guidance
Coronary Vein Morphogenesis
Primitive Erythrocyte Differentiation
VEGF-activated Neuropilin Signaling Pathway
Lymphotoxin A Biosynthetic Process
Interleukin-6 Biosynthetic Process
Response To Stimulus
Regulation Of Proteolysis
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing
Positive Regulation Of Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Histone Deacetylase Activity
Tube Formation
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Chordate Embryonic Development
Positive Regulation Of Lymphangiogenesis
Cardiac Vascular Smooth Muscle Cell Development
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Positive Regulation Of Mast Cell Chemotaxis
Negative Regulation Of Mature B Cell Apoptotic Process
Regulation Of Retinal Ganglion Cell Axon Guidance
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Embryo Development Ending In Birth Or Egg Hatching
Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway
Regulation Of Histone Deacetylase Activity
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Immune System Process
Interleukin-6 Production
Positive Regulation Of Deacetylase Activity
Coronary Artery Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Cardiac Vascular Smooth Muscle Cell Differentiation
Apoptotic Process
Negative Regulation Of Cell Death
Positive Regulation Of Interleukin-8 Biosynthetic Process
Positive Regulation Of Axon Extension Involved In Axon Guidance
Cardiac Muscle Fiber Development
Programmed Cell Death
Tagcloud
?
autophagy
bcl2
birc5
buffer
constituents
damaged
dataset
degrades
deregulation
distant
eif4ebp1
ero1l
fos
gapdh
gse21653
gse3494
gse7390
inc
itpr1
lived
organelles
periodicals
prognostic
proportional
shortened
signature
starvation
subgroups
wiley
Tagcloud (Difference)
?
autophagy
bcl2
birc5
buffer
constituents
damaged
dataset
degrades
deregulation
distant
eif4ebp1
ero1l
fos
gapdh
gse21653
gse3494
gse7390
inc
itpr1
lived
organelles
periodicals
prognostic
proportional
shortened
signature
starvation
subgroups
wiley
Tagcloud (Intersection)
?