TGFB3 and TGFBR3

Number of citations of the paper that reports this interaction (PMID 11382746)
18

Data Source:
HPRD (in vitro)

		TGFB3	TGFBR3
Gene Name		transforming growth factor, beta 3	transforming growth factor, beta receptor III
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface T-tubule Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body	Proteinaceous Extracellular Matrix Extracellular Space Endoplasmic Reticulum Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Protein Heterodimerization Activity Transforming Growth Factor Beta Binding	Transforming Growth Factor Beta-activated Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding Coreceptor Activity Fibroblast Growth Factor Binding PDZ Domain Binding SMAD Binding Activin Binding Transforming Growth Factor Beta Binding Transforming Growth Factor Beta Receptor Activity, Type III
	Biological Process	Activation Of MAPK Activity Response To Hypoxia In Utero Embryonic Development Platelet Degranulation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Salivary Gland Morphogenesis Female Pregnancy Aging Blood Coagulation Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Cell Growth Platelet Activation Extracellular Matrix Organization Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Response To Laminar Fluid Shear Stress Regulation Of Cell Proliferation Odontogenesis Uterine Wall Breakdown Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Ossification Involved In Bone Remodeling Cell-cell Junction Organization Positive Regulation Of DNA Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Digestive Tract Development Embryonic Neurocranium Morphogenesis Inner Ear Development Positive Regulation Of Protein Secretion Positive Regulation Of Filopodium Assembly Positive Regulation Of Cell Division Palate Development Face Morphogenesis Frontal Suture Morphogenesis Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Detection Of Hypoxia	Blood Vessel Development Response To Hypoxia Blastocyst Development Epithelial To Mesenchymal Transition Liver Development Heart Morphogenesis Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Complex Assembly Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Cell Growth Cell Migration BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Response To Follicle-stimulating Hormone Response To Prostaglandin E Response To Luteinizing Hormone Intracellular Signal Transduction Regulation Of Protein Binding Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cellular Component Movement Ventricular Cardiac Muscle Tissue Morphogenesis Palate Development Cardiac Muscle Cell Proliferation Definitive Hemopoiesis Cardiac Epithelial To Mesenchymal Transition Definitive Erythrocyte Differentiation Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation
Pathways		Molecules associated with elastic fibres Elastic fibre formation Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Bone mineral density ( 19249006) Optic disc parameters ( 20548946 21307088) Type 2 diabetes ( 23209189)
Protein-Protein Interactions		13 interactors: ACVRL1 CCL20 CHMP2A CTGF ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN	13 interactors: ACVR2A ARRB2 ENG GIPC1 INHA INHBA NRP1 SDC2 TCTEX1D4 TGFB1 TGFB2 TGFB3 TGFBR2
Entrez ID		7043	7049
HPRD ID		01829	02846
Ensembl ID			ENSG00000069702
Uniprot IDs		A5YM40 B3KVH9 P10600	Q03167
PDB IDs		1KTZ 1TGJ 1TGK 2PJY 3EO1
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cartilage Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Blood Vessel Development Vasculature Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Angiogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Component Movement Response To Wounding Tube Development Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Chondrocyte Differentiation Blood Vessel Morphogenesis Positive Regulation Of Protein Metabolic Process Cell Migration Response To Lipid Positive Regulation Of Phosphorylation Cardiovascular System Development Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Cell Proliferation Skeletal System Morphogenesis Skeletal System Development Extracellular Matrix Constituent Secretion Regulation Of Epithelial Cell Proliferation Organ Morphogenesis Regulation Of Cell Migration Regulation Of Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Wound Healing Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Phosphorus Metabolic Process Response To Growth Factor Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Response To Wounding Negative Regulation Of Macrophage Cytokine Production Negative Regulation Of Cytokine Production Regulation Of Signal Transduction Ovulation Cycle Process Positive Regulation Of Ossification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ovulation Cycle Regulation Of Signaling Skeletal System Development Positive Regulation Of Bone Mineralization Wound Healing Regulation Of Cell Differentiation Positive Regulation Of Biomineral Tissue Development Regulation Of MAPK Cascade Salivary Gland Morphogenesis SMAD Protein Import Into Nucleus Cell Growth Salivary Gland Development Negative Regulation Of Cell Proliferation Gland Morphogenesis Response To Organic Substance Negative Regulation Of Immune System Process Positive Regulation Of Cellular Metabolic Process Signal Transduction Negative Regulation Of Signaling Single Organism Reproductive Process Exocrine System Development
Tagcloud ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfa thra1 transforming transmission trios utilizing	5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically zfp423
Tagcloud (Difference) ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfa thra1 transforming transmission trios utilizing	5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically zfp423
Tagcloud (Intersection) ?