TGFB3 and LTBP3

Number of citations of the paper that reports this interaction (PMID 12062452)
8

Data Source:
HPRD (in vivo)

		TGFB3	LTBP3
Gene Name		transforming growth factor, beta 3	latent transforming growth factor beta binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Cell Surface T-tubule Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body	Extracellular Region Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Protein Heterodimerization Activity Transforming Growth Factor Beta Binding	Calcium Ion Binding Transforming Growth Factor Beta Binding
	Biological Process	Activation Of MAPK Activity Response To Hypoxia In Utero Embryonic Development Platelet Degranulation Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Salivary Gland Morphogenesis Female Pregnancy Aging Blood Coagulation Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Cell Growth Platelet Activation Extracellular Matrix Organization Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Response To Laminar Fluid Shear Stress Regulation Of Cell Proliferation Odontogenesis Uterine Wall Breakdown Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Ossification Involved In Bone Remodeling Cell-cell Junction Organization Positive Regulation Of DNA Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lung Alveolus Development Digestive Tract Development Embryonic Neurocranium Morphogenesis Inner Ear Development Positive Regulation Of Protein Secretion Positive Regulation Of Filopodium Assembly Positive Regulation Of Cell Division Palate Development Face Morphogenesis Frontal Suture Morphogenesis Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Detection Of Hypoxia	Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Negative Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Transforming Growth Factor Beta Activation Positive Regulation Of Bone Resorption Bone Remodeling Bone Morphogenesis Lung Saccule Development Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Molecules associated with elastic fibres Elastic fibre formation Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS			Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Urate levels ( 23263486)
Protein-Protein Interactions		13 interactors: ACVRL1 CCL20 CHMP2A CTGF ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN	12 interactors: CACNA1A CCNG1 GORASP2 HBEGF ITGB5 PELI2 PIK3R2 PRPF40A RAC1 TGFB1 TGFB2 TGFB3
Entrez ID		7043	4054
HPRD ID		01829	03649
Ensembl ID			ENSG00000168056
Uniprot IDs		A5YM40 B3KVH9 P10600	B9EG76 Q8WYU6 Q9NS15
PDB IDs		1KTZ 1TGJ 1TGK 2PJY 3EO1
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cartilage Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Blood Vessel Development Vasculature Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Angiogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Component Movement Response To Wounding Tube Development Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Chondrocyte Differentiation Blood Vessel Morphogenesis Positive Regulation Of Protein Metabolic Process Cell Migration Response To Lipid Positive Regulation Of Phosphorylation Cardiovascular System Development Cell Motility Positive Regulation Of Protein Modification Process Regulation Of Cell Proliferation Skeletal System Morphogenesis Skeletal System Development Extracellular Matrix Constituent Secretion Regulation Of Epithelial Cell Proliferation Organ Morphogenesis Regulation Of Cell Migration Regulation Of Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Wound Healing Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation	Negative Regulation Of Macrophage Cytokine Production Cellular Response To Growth Factor Stimulus Response To Growth Factor SMAD Protein Import Into Nucleus Cell Growth Regulation Of Cell Morphogenesis Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Wound Healing Uterine Wall Breakdown Tissue Remodeling Response To Wounding Positive Regulation Of Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Signaling Pathway Face Morphogenesis Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Cell Morphogenesis Involved In Differentiation Head Morphogenesis Head Development Positive Regulation Of Intracellular Signal Transduction Blood Coagulation Ossification Involved In Bone Remodeling Hemostasis Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Migration Salivary Gland Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Salivary Gland Development Cell Surface Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Response To Transforming Growth Factor Beta Platelet Activation Frontal Suture Morphogenesis Response To Progesterone Regulation Of Phosphorus Metabolic Process Face Development Cell Motility Positive Regulation Of Stem Cell Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Growth SMAD Protein Signal Transduction Negative Regulation Of Cytokine Production Regulation Of Epithelial To Mesenchymal Transition Cell-cell Junction Organization Regulation Of Lipid Kinase Activity Bone Remodeling Exocrine System Development Body Morphogenesis
Tagcloud ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfa thra1 transforming transmission trios utilizing	albeit causal contributor correlates define differ differing doi dx ecm egln1 elife http identifies mammary matrix metastatic org proteomics s100a2 serve signatures sned1 steps stroma stromal tgfbeta tools xenografts
Tagcloud (Difference) ?		alleles bcl3 cleft clefts conditional covariates d19s178 definitive disequilibrium ethnic incorporated incorporating lip modestly modifiers odds offspring parent permitting probands proto stratification tdt tgfa thra1 transforming transmission trios utilizing	albeit causal contributor correlates define differ differing doi dx ecm egln1 elife http identifies mammary matrix metastatic org proteomics s100a2 serve signatures sned1 steps stroma stromal tgfbeta tools xenografts
Tagcloud (Intersection) ?