STX11 and MFAP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		STX11	MFAP1
Description		syntaxin 11	microfibril associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Endomembrane System Membrane SNARE Complex Presynaptic Active Zone Membrane	Microfibril Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex Centrosome U2-type Precatalytic Spliceosome
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Binding	RNA Binding Protein Binding
	Biological Process	Intracellular Protein Transport Exocytosis Protein Transport Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Docking Membrane Fusion	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases		Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
GWAS		Nicotine dependence symptom count ( 25555482) Pre-treatment viral load in HIV-1 infection ( 31219150)	Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643)
Interacting Genes		98 interacting genes: AIRIM APP AXIN1 AXIN2 BLOC1S6 BYSL CARD9 CCBE1 CCDC120 CCDC125 CCDC184 CCDC196 CCDC33 CCHCR1 CCNK CDCA7L CDR2L CRYBA4 CTBP2 CWF19L2 DISC1 DUSP29 EIF1AD EIF2B5 FAM110A FAM161A FAM161B FAM74A4 FAM90A1 FARS2 GOLGA8EP GOLGA8F HAUS1 HGS HOXA1 IKBKG IKZF3 KAT5 KCTD9 KDM1A KIFC3 KLC3 KRT75 KXD1 LENG1 LONRF1 MAGOHB MBD3L1 MBIP MEOX2 MFAP1 MID2 MIS18A MTCL2 NDC80 NTAQ1 PKN1 PPP1R18 PRKAB2 PRPF18 PRPF31 PSMA3 PSMC3 RAD51D RNF6 RNF8 RNPS1 RUNX1T1 SCNM1 SH2D4A SHC3 SIKE1 SLC38A2 SMARCE1 SNAP23 SNAP25 SNCA SNX3 STX1A STX4 SUV39H1 TADA3 TAF6L TBK1 TCEA2 TCF4 TLE5 TNFRSF21 TRIM41 TSGA10IP UBASH3A USHBP1 VAMP2 VPS52 ZCCHC10 ZNF19 ZNF417 ZNF587	88 interacting genes: ALKBH8 AMOTL2 AP2M1 BEND7 BICD2 CARD9 CCDC102B CCDC33 CCDC57 CDC14B CDCA7L CEP55 CEP57L1 CEP70 CEP76 COG6 CSNK2A1 DHX38 DHX8 DNTTIP1 DRC4 FAM9B FRA10AC1 FXR1 FXR2 GKAP1 GOLGA2 GOLGA6L9 GPRASP3 GRIPAP1 HMBOX1 HOMER3 HOOK2 HSF2BP HSPB1 IK KATNBL1 KIFC3 KLHL2 KRT40 L3MBTL3 LDOC1 LMNA LMNB2 LZTS1 MAD1L1 MCRS1 MID2 MIPOL1 MTUS2 NDC80 NGDN OGT OLIG3 PAX6 PHC2 PIBF1 PIH1D1 PLEKHF2 SNW1 SSX2IP STAC3 STX11 TADA2A TCP10L TEPSIN TFIP11 THAP1 TLE5 TRAF2 TRIM41 TRIM42 TRIM54 U2AF1 VPS52 YWHAG ZBTB1 ZBTB14 ZBTB8A ZFP1 ZFP41 ZFP64 ZNF398 ZNF41 ZNF558 ZNF620 ZNF71 ZNF76
Entrez ID		8676	4236
HPRD ID		09231	02569
Ensembl ID		ENSG00000135604	ENSG00000140259
Uniprot IDs		O75558	P55081
PDB IDs			5F5S 5O9Z 6AHD 7AAV 7ABF 7ABG 7ABI 8H6K 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex SNARE Complex Assembly Protein Binding SNAP Receptor Activity SNARE Complex Synaptic Vesicle Docking Synaptic Vesicle Exocytosis SNARE Binding Regulation Of Cellular Response To Stress Regulation Of DNA Repair BLOC-1 Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptic Vesicle Priming Establishment Of Localization In Cell Membrane Docking Establishment Of Organelle Localization Positive Regulation Of Proteolysis Positive Regulation Of Synaptic Transmission Syntaxin Binding Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Regulation Of RNA Metabolic Process Transcription Coactivator Activity Neurotransmitter Transport Vesicle Fusion Membrane Fusion Long-term Synaptic Potentiation Regulation Of Gene Expression Organelle Membrane Fusion Organelle Localization Establishment Of Vesicle Localization Host-mediated Perturbation Of Symbiont Process DNA Repair-dependent Chromatin Remodeling Regulation Of DNA-templated Transcription Nuclear Androgen Receptor Binding Vesicle Organization Vesicle Docking Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Modulation Of Process Of Another Organism Microtubule-based Process Vesicle Localization Neuron Projection Nucleoplasm	Identical Protein Binding Protein Binding Nucleus Microtubule Binding Cytoskeleton Centrosome Nuclear Pore Localization Zinc Ion Binding Microtubule-based Process Organelle Organization Microtubule Cytoskeleton Organization TORC1 Complex Assembly MRNA Splicing, Via Spliceosome Protein Kinase C Inhibitor Activity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Catalytic Step 2 Spliceosome Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Spindle Pole Response To Muramyl Dipeptide Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Spliceosomal Complex Microtubule Negative Regulation Of Metabolic Process Intracellular Protein Localization Cytoskeleton Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Macromolecule Metabolic Process Membraneless Organelle Assembly Regulation Of Chromosome Separation Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Negative Regulation Of Chromosome Organization Chromosome Localization Negative Regulation Of Macromolecule Metabolic Process ATP-dependent Activity, Acting On RNA Mitotic Spindle Pole Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Mitotic Nuclear Division Cellular Response To Muramyl Dipeptide Nucleus Organization Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint NSL Complex
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