SYT6 and LZTS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYT6	LZTS1
Description		synaptotagmin 6	leucine zipper tumor suppressor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Exocytic Vesicle Perinuclear Endoplasmic Reticulum	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Cell Projection Dendritic Spine Synapse Glutamatergic Synapse
	Molecular Function	SNARE Binding Protein Binding Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Protein Homodimerization Activity Metal Ion Binding Calcium Ion Sensor Activity	Protein Binding
	Biological Process	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Acrosomal Vesicle Exocytosis	Negative Regulation Of Macroautophagy Regulation Of Synaptic Plasticity Regulation Of Dendrite Morphogenesis Regulation Of Postsynapse Assembly
Pathways
Drugs
Diseases
GWAS		Breast cancer (prognosis) ( 23319801) Obesity-related traits ( 23251661) Refractive error ( 32231278)	Adult body size ( 32376654) Circulating myeloperoxidase levels (serum) ( 23620142) Dental caries ( 23064961 23259602) Femur bone mineral density x serum urate levels interaction ( 34046847) Influenza A (H1N1) infection ( 26379185) Interleukin-6 levels ( 33517400) Major depressive disorder (broad) ( 20038947) Persistent hepatitis B virus infection ( 27244555) Preeclampsia ( 23551011) Rheumatoid arthritis ( 30891314) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		30 interacting genes: APP BRCA1 CCDC136 CCDC57 CNTROB DVL3 FXR1 FXR2 GMCL1 GOLGA2 HMBOX1 HOOK2 KANK2 KCTD9 KIF24 KIFC3 KRT40 LMNA LZTS1 MAD1L1 MCC MTUS2 NRXN1 PRKCB TNIP1 TRIM27 TRIM32 TSGA10 ZBTB43 ZBTB8A	100 interacting genes: AGTR1 AMOT AP1M1 BYSL CARD9 CCDC102B CCDC120 CCDC13 CCDC187 CCDC57 CCHCR1 CDC23 CDC25C CDC37 CDC7 CDK1 CEP83 CKS1B COG2 COPB1 CWF19L2 DDX6 DRC4 EEF1G ELOA ENKD1 EXOC8 FAM161A FAM161B FAM50B FAM81B FAM90A1 GARIN1B GOLGA1 GPKOW HMGB2 IDO2 KANK2 KAT5 KAZN KDM1A KIF9 KIFC3 LENG1 LMNB2 LMO1 LMO2 LMO3 LMO4 LNX1 LSM2 MAPK9 MCRS1 METTL21A MFAP1 MID2 MTCL2 NEK6 NTAQ1 PIBF1 PICK1 PLEKHA7 POLR1C POLR3C PPP1R18 PRKAB2 PRPF18 PRPF3 PSMA1 PSPC1 QARS1 RABIF RHPN1 RSPH14 RUNX1T1 SCNM1 SGF29 SPDYC SUFU SYT17 SYT6 SYTL4 TBC1D1 TBC1D7 TCEA2 TSGA10 TSGA10IP TTC9C TXLNA TXLNB TXNDC9 UBASH3A ZGPAT ZMYND19 ZNF250 ZNF3 ZNF35 ZNF417 ZNF572 ZNF587
Entrez ID		148281	11178
HPRD ID		09654	05945
Ensembl ID		ENSG00000134207	ENSG00000061337
Uniprot IDs		A0A7I2PMW4 I6L9C3 Q5T7P8	Q9Y250
PDB IDs			8Y1U
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Centrosome Microtubule-based Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Microtubule Organizing Center Organization Nuclear Pore Localization NMDA Selective Glutamate Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Microtubule Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cytoskeleton Regulation Of Cell Projection Organization Regulation Of Organelle Organization Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Component Organization Organelle Assembly Centriole Acetylcholine Receptor Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Microtubule Negative Regulation Of Viral Process Cytoplasm Negative Regulation Of Viral Transcription Cellular Component Assembly Suppression Of Viral Release By Host Regulation Of Synaptic Plasticity Translation Regulator Activity Negative Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Viral Transcription Presynapse Positive Regulation Of RNA Metabolic Process Organelle Organization Regulation Of Cell Projection Assembly Regulation Of Cilium Assembly Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Cilium Assembly Centriole Replication Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Regulation Of Presynapse Organization Regulation Of Presynapse Assembly	Protein Binding Cytoskeleton DNA-binding Transcription Factor Binding Centrosome Centriole Nucleoplasm Cilium Organization Microtubule Cytoskeleton Organization Zonula Adherens Maintenance Cytoplasm
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