SYT6 and TSGA10

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SYT6	TSGA10
Description		synaptotagmin 6	testis specific 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Exocytic Vesicle Perinuclear Endoplasmic Reticulum	Cytoplasm Centriole Cytoskeleton Motile Cilium Sperm Fibrous Sheath Neuron Projection Sperm Principal Piece
	Molecular Function	SNARE Binding Protein Binding Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Protein Homodimerization Activity Metal Ion Binding Calcium Ion Sensor Activity	Protein Binding
	Biological Process	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Acrosomal Vesicle Exocytosis	Spermatogenesis Cell Projection Assembly
Pathways
Drugs
Diseases
GWAS		Breast cancer (prognosis) ( 23319801) Obesity-related traits ( 23251661) Refractive error ( 32231278)	Bipolar disorder ( 21926972) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		30 interacting genes: APP BRCA1 CCDC136 CCDC57 CNTROB DVL3 FXR1 FXR2 GMCL1 GOLGA2 HMBOX1 HOOK2 KANK2 KCTD9 KIF24 KIFC3 KRT40 LMNA LZTS1 MAD1L1 MCC MTUS2 NRXN1 PRKCB TNIP1 TRIM27 TRIM32 TSGA10 ZBTB43 ZBTB8A	81 interacting genes: AARD AXIN1 AXIN2 BCL6B BIRC2 CBX8 CBY2 CCDC136 CCDC33 CCDC88B CCHCR1 CDC73 CDK18 CDSN CEP44 CEP57 CEP57L1 COG6 CREB5 DISC1 FAM161A FAM161B FBF1 GCC2-AS1 GOLGA2 HDAC4 HDX HIF1A HNRNPM HOOK2 JRK KANK2 KIAA1328 KRT6A KRT76 LMNA LZTS1 MAD1L1 MATR3 MBD3L1 MID2 NAB2 PAK5 PIBF1 PKN1 PLEKHA7 PPHLN1 PPP1R13B PPP1R18 PRDM14 PRDM6 PRPF31 RBAK RCOR3 RNF6 RTP5 SCEL SORBS3 SYT6 TCEA2 TLE5 TP53BP2 TRIM14 TRIM29 ZBTB24 ZBTB26 ZBTB38 ZBTB39 ZNF124 ZNF2 ZNF205 ZNF23 ZNF410 ZNF417 ZNF426 ZNF438 ZNF490 ZNF544 ZNF587 ZNF599 ZNF670
Entrez ID		148281	80705
HPRD ID		09654	06202
Ensembl ID		ENSG00000134207	ENSG00000135951
Uniprot IDs		A0A7I2PMW4 I6L9C3 Q5T7P8	A0A218MIY9 Q9BZW7
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Centrosome Microtubule-based Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Microtubule Organizing Center Organization Nuclear Pore Localization NMDA Selective Glutamate Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission Microtubule Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Cytoskeleton Regulation Of Cell Projection Organization Regulation Of Organelle Organization Regulation Of Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Component Organization Organelle Assembly Centriole Acetylcholine Receptor Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Microtubule Negative Regulation Of Viral Process Cytoplasm Negative Regulation Of Viral Transcription Cellular Component Assembly Suppression Of Viral Release By Host Regulation Of Synaptic Plasticity Translation Regulator Activity Negative Regulation Of Signal Transduction Regulation Of Cellular Component Organization Regulation Of Viral Transcription Presynapse Positive Regulation Of RNA Metabolic Process Organelle Organization Regulation Of Cell Projection Assembly Regulation Of Cilium Assembly Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Cilium Assembly Centriole Replication Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Regulation Of Presynapse Organization Regulation Of Presynapse Assembly	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Biosynthetic Process Centrosome Negative Regulation Of Metabolic Process P53 Binding Negative Regulation Of Macromolecule Metabolic Process Microtubule Binding Metal Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Wnt Signaling Pathway
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