IGFL2 and TLX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IGFL2	TLX3
Description		IGF like family member 2	T cell leukemia homeobox 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleus Nucleoplasm
	Molecular Function	Signaling Receptor Binding Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Neuron Differentiation Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification GABAergic Neuron Differentiation
Pathways
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS			Body size at age 10 ( 32376654)
Interacting Genes		3 interacting genes: PITX1 PLEKHA7 TLX3	108 interacting genes: ACTMAP ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C2orf42 CEACAM6 CFAP68 CIMIP2B CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNF1B HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KCNJ5-AS1 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NFIC NFIX NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPMIP9 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 THTPA TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44
Entrez ID		147920	30012
HPRD ID		13729	06868
Ensembl ID		ENSG00000204866	ENSG00000164438
Uniprot IDs		Q6UWQ7	O43711
PDB IDs
Enriched GO Terms of Interacting Partners?		Branchiomeric Skeletal Muscle Development Myoblast Fate Commitment Zonula Adherens Maintenance Regulation Of Respiratory Gaseous Exchange By Nervous System Process GABAergic Neuron Differentiation Pore Complex Zonula Adherens Adherens Junction Maintenance Delta-catenin Binding Sequence-specific Double-stranded DNA Binding Regulation Of Respiratory System Process Epithelial Cell-cell Adhesion Pore Complex Assembly DNA-binding Transcription Factor Activity Embryonic Hindlimb Morphogenesis Pituitary Gland Development Respiratory Gaseous Exchange By Respiratory System Neuron Fate Specification Regulation Of Respiratory Gaseous Exchange Cell-cell Junction Maintenance Hindlimb Morphogenesis Cell-cell Adhesion Mediated By Cadherin Cell Junction Maintenance Adherens Junction Organization	Intermediate Filament Protein Binding Chromatin
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