ZNF417 and RHOQ

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF417	RHOQ
Description		zinc finger protein 417	ras homolog family member Q
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Actin Filament Plasma Membrane Membrane Golgi-associated Vesicle Membrane Membrane Raft Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding GTPase Activity Protein Binding Profilin Binding GTP Binding Protein Kinase Binding GBD Domain Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Endocytosis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Establishment Of Cell Polarity Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription By RNA Polymerase II GTP Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of Filopodium Assembly Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Generic Transcription Pathway	Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle
Drugs
Diseases
GWAS		Depression in smokers ( 30219690)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		170 interacting genes: - ADAMTSL4 AXIN2 BEGAIN BEND5 BEX3 BICD2 C4orf17 CARD9 CBY2 CCDC125 CCDC136 CCDC57 CCDC85B CCNDBP1 CDR2 CDR2L CEP44 CEP70 CEP72 CEP85L CHRDL2 COG6 CSRNP1 CYSRT1 DEF8 DVL3 EFS EZHIP FAM221A FHL2 FHL3 FHL5 FRS3 FSD2 FXR1 GOLGA2 GOLGA6L9 GPRASP3 HMBOX1 HOMEZ HOOK2 HOXA1 HSF2BP IGFBP6 IHO1 IKZF1 INKA1 JADE2 JRK KAT5 KATNBL1 KCTD7 KIF9 KIFC3 KLC3 KRT15 KRT31 KRT35 KRT38 KRT39 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-9 KXD1 LHX3 LIMS1 LMO1 LURAP1 LZTS1 LZTS2 MAGEA8 MAST2 MCC MCCD1 MDFI MEIS3 MEOX2 MID2 MIIP MRFAP1L1 MTUS2 MYF5 MYLIP NAB2 NBPF19 NDEL1 NDUFB7 NINL NKAPL NKX3-1 NOTCH2NLA OIP5 PHC2 PICK1 PIH1D2 PLSCR1 PNMA2 PRICKLE4 PRPF31 RCN3 REL RHOQ RNF187 RORB RPGRIP1 RUNDC3A SH2B2 SMARCD1 SMYD5 SPRED1 SPRED2 SPRY1 SPRY2 SSX2IP STX11 SUV39H1 TADA2A TCF4 TEKT4 TFIP11 TLE5 TMCC2 TNS2 TRAF1 TRAF2 TRIB3 TRIM23 TRIM27 TRIM36 TRIM37 TRIM41 TRIM54 TSC1 TSGA10 TXNDC11 U2AF1 USHBP1 VPS16 VPS52 VWC2 ZBTB1 ZBTB10 ZBTB43 ZBTB8A ZBTB9 ZNF165 ZNF19 ZNF20 ZNF547 ZNF572 ZNF587 ZNF69 ZNF71 ZNF768 ZNF774 ZNF837 ZNF85 ZRANB1	22 interacting genes: BANP CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DOCK8 EXOC7 GOPC MORN4 NTAQ1 PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL ZNF417
Entrez ID		147687	23433
HPRD ID		18341	05791
Ensembl ID		ENSG00000173480	ENSG00000119729
Uniprot IDs		M0R230 Q8TAU3	P17081 V9HWD0
PDB IDs			2ATX
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Protein Binding Identical Protein Binding Zinc Ion Binding Negative Regulation Of Lens Fiber Cell Differentiation Regulation Of Lens Fiber Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Structural Constituent Of Skin Epidermis Cytoskeleton Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Microtubule Binding Cytoskeleton Organization Microtubule-based Process Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Microtubule DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Organelle Organization Hair Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Stem Cell Factor Receptor Binding	Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Cell Projection Organization Cytoplasm PAR Polarity Complex Positive Regulation Of Protein Polymerization Cytosol Regulation Of Cell Projection Assembly Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Small GTPase-mediated Signal Transduction Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Organization Small GTPase Binding Rho Protein Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Cytoskeleton Tight Junction Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Regulation Of Cell Shape Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Cell Leading Edge Regulation Of Actin Cytoskeleton Organization Cell Cortex Actin Cytoskeleton Organization Plasma Membrane COPI Vesicle Coat Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Actin Filament-based Process COPI-coated Vesicle Membrane Regulation Of Protein-containing Complex Assembly Regulation Of Cell Morphogenesis Cell Junction Organization Endomembrane System Positive Regulation Of Organelle Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cytoskeleton Organization Bicellular Tight Junction Membrane Coat Intracellular Signaling Cassette Centriolar Satellite
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