CSH1 and PTPN12

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CSH1	PTPN12
Gene Name		chorionic somatomammotropin hormone 1 (placental lactogen)	protein tyrosine phosphatase, non-receptor type 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Podosome Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection
	Molecular Function	Hormone Activity Metal Ion Binding	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs
Diseases
GWAS		Height ( 23563607)
Protein-Protein Interactions		6 interactors: PRLR PSMD9 PTPN12 SMAD2 SMAD4 SMAD9	37 interactors: ABL1 APP BAG6 BCAR1 CGA CSH1 CSH2 CSK EFS EGFR FLT3 GRB2 IFT20 INSR JAK2 LPXN MYCBP2 NEDD9 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PXN RBM19 SHC1 SMAD5 SORBS2 STX16 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2
Entrez ID		1442	5782
HPRD ID		08350	02513
Ensembl ID		ENSG00000136488	ENSG00000127947
Uniprot IDs		A6NFB4 A8K6C2 P01243	A4D1C5 B4E105 E9PBR5 Q05209
PDB IDs		1Z7C
Enriched GO Terms of Interacting Partners?		Cellular Protein Complex Assembly Urogenital System Development Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development SMAD Protein Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Kidney Epithelium Development Cellular Macromolecular Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Intracellular Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Developmental Growth Positive Regulation Of BMP Signaling Pathway Kidney Development Renal System Development Protein Complex Assembly Positive Regulation Of Stem Cell Differentiation Epithelium Development Embryonic Axis Specification Regulation Of Epithelial To Mesenchymal Transition SMAD Protein Signal Transduction Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Somatic Stem Cell Maintenance Positive Regulation Of Transcription, DNA-templated BMP Signaling Pathway Growth Endoderm Development Embryonic Pattern Specification Regulation Of BMP Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Organ Growth Positive Regulation Of Gene Expression Cellular Protein Modification Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Palate Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Metabolic Process Axis Specification Tissue Development Tube Development	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Adhesion Protein Autophosphorylation Cellular Response To Organonitrogen Compound Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Response To Organonitrogen Compound Cell Activation Regulation Of Protein Kinase Activity Blood Coagulation Peptidyl-tyrosine Autophosphorylation Hemostasis Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Hormone Stimulus Cellular Response To Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide Signal Transduction Regulation Of Kinase Activity Regulation Of MAPK Cascade Innate Immune Response Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Phosphorylation Cell Communication Regulation Of MAP Kinase Activity Peptidyl-amino Acid Modification Response To Hormone Cellular Response To Growth Factor Stimulus Platelet Activation Regulation Of Body Fluid Levels Response To Growth Factor Wound Healing Locomotion Response To Peptide Hormone Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Migration Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Kinase Activity Protein Phosphorylation Immune System Process Regulation Of Immune System Process Regulation Of Phosphorylation Response To Peptide
Tagcloud ?		anchor autosomes bovine cattle chrnb1 chromosome chromosomes comparative completes conservation cryb1 distributed exception hamster homologue largest loci mapped mapping mpo myl4 nf1 p4hb pl1 reveals segment synteny thra1 true	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		anchor autosomes bovine cattle chrnb1 chromosome chromosomes comparative completes conservation cryb1 distributed exception hamster homologue largest loci mapped mapping mpo myl4 nf1 p4hb pl1 reveals segment synteny thra1 true	cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol inpp5d mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?