CSH1 and PRLR

Number of citations of the paper that reports this interaction (PubMedID 10966654)
0

Data Source:
HPRD (in vitro)

		CSH1	PRLR
Description		chorionic somatomammotropin hormone 1	prolactin receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endomembrane System Endosome Lumen Vesicle	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endosome Lumen Receptor Complex
	Molecular Function	Growth Hormone Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding	Cytokine Receptor Activity Prolactin Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Protein Kinase Binding Cytokine Binding Metal Ion Binding
	Biological Process	Response To Nutrient Levels Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Growth Hormone Receptor Signaling Pathway	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Response To Bacterium Cytokine-mediated Signaling Pathway Regulation Of Cell Adhesion Regulation Of Epithelial Cell Differentiation Positive Regulation Of B Cell Proliferation Prolactin Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Mammary Gland Epithelial Cell Differentiation Prostate Gland Growth Mammary Gland Alveolus Development Mammary Gland Epithelium Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Cold-induced Thermogenesis
Pathways		Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling	Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Lonapegsomatropin
Diseases
GWAS		Height ( 23563607 25429064 31562340)	Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Chronotype ( 30696823) DHEAS levels ( 34748635) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		7 interacting genes: PRLR PSMD9 PTPN12 SGTB SMAD2 SMAD4 SMAD9	20 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 INSIG2 JAK2 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		1442	5618
HPRD ID		08350	01457
Ensembl ID		ENSG00000136488	ENSG00000113494
Uniprot IDs		A8K6C2 P0DML2	P16471
PDB IDs		1Z7C	1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Activin Responsive Factor Complex Response To Growth Factor Developmental Growth Transforming Growth Factor Beta Receptor Signaling Pathway Secondary Palate Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway R-SMAD Binding Activin Receptor Signaling Pathway Embryonic Axis Specification Cellular Response To BMP Stimulus Endoderm Development Transcription Regulator Complex Cellular Response To Growth Factor Stimulus Gastrulation Organ Growth SMAD Binding Mesoderm Development Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Intracellular Iron Ion Homeostasis Roof Of Mouth Development Epithelial Cell Differentiation Response To Transforming Growth Factor Beta Axis Specification Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis BMP Signaling Pathway Homomeric SMAD Protein Complex Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Prolactin Receptor Activity TRC Complex Stem Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Hormone Levels Zygotic Specification Of Dorsal/ventral Axis Response To Glucose Ameboidal-type Cell Migration Paraxial Mesoderm Morphogenesis Osteoblast Differentiation Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity	Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Binding Protein Modification Process Regulation Of Signal Transduction Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Endosome Lumen Growth Hormone Receptor Signaling Pathway Intracellular Signal Transduction Vesicle Positive Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Phosphorylation-dependent Protein Binding Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Prolactin Receptor Binding Positive Regulation Of Immune System Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Signal Transduction Cytokine Receptor Binding Developmental Process Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Activation Regulation Of Immune System Process Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Sequestering Activity
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