HSPB6 and HSPB8

Number of citations of the paper that reports this interaction (PMID 16225851)
15

Data Source:
HPRD (in vivo, two hybrid)

		HSPB6	HSPB8
Gene Name		heat shock protein, alpha-crystallin-related, B6	heat shock 22kDa protein 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Intracellular Nucleus Nucleoplasm Cytoplasm Golgi Apparatus
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Protein Homodimerization Activity	Protein Kinase Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Muscle Contraction	Biological_process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: HSPB8 SNCA YWHAG	13 interactors: BAG3 CRYAB CSNK2A1 DUSP12 HSPB1 HSPB2 HSPB3 HSPB6 HSPB7 MAPK3 PRKCA QRICH1 SNCA
Entrez ID		126393	26353
HPRD ID		08130	06420
Ensembl ID		ENSG00000004776	ENSG00000152137
Uniprot IDs		O14558	Q9UJY1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Regulation Of Synaptic Plasticity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Intracellular Transport Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Synaptic Transmission Negative Regulation Of Protein Phosphorylation Response To Iron(II) Ion Cellular Response To Copper Ion Negative Regulation Of Phosphorylation Regulation Of Synaptic Vesicle Recycling Regulation Of Intracellular Transport Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cellular Response To Organonitrogen Compound Regulation Of Oxidative Phosphorylation Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Dopamine Transport Regulation Of Glutamate Secretion Dopamine Biosynthetic Process Negative Regulation Of Monooxygenase Activity Neurotransmitter Uptake Regulation Of Cellular Respiration Microglial Cell Activation Extracellular Fibril Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Positive Regulation Of Apoptotic Process Regulation Of Neurotransmitter Uptake Negative Regulation Of Microtubule Polymerization Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Programmed Cell Death Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Cell Death Cellular Response To Epinephrine Stimulus Positive Regulation Of Receptor Recycling Catecholamine Biosynthetic Process Regulation Of Synaptic Transmission, Dopaminergic Response To Epinephrine	Response To Unfolded Protein Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Regulation Of Catalytic Activity Cell Death Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Response To Organic Substance Response To Interleukin-1 Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Chromosome Organization Cellular Response To Growth Factor Stimulus Response To External Stimulus Negative Regulation Of Nucleotide Metabolic Process Response To Growth Factor Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Histone Acetylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Cell Activation Negative Regulation Of Peptidase Activity Regulation Of Phosphorylation Positive Regulation Of Endothelial Cell Migration Protein Folding Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Apolipoprotein Binding Positive Regulation Of Dense Core Granule Biogenesis
Tagcloud ?		3gamma 3zeta abundant actual anions check destabilized glycerol governing hsp20 huge hypothesized inorganic interaction monomeric obscure participating partners phosphate phosphointeractome phosphorylated physiological physiologically presumably pyrophosphate sulfate theoretically undergoes	accordingly ala antiestrogens antiprogestins cdk2 cdks coactivators copurified cos deregulation disrupted g2 insensitive keys lysates pr probed progesterone progestin prs roscovitine s345a ser345 sp1 synchronized t47d talk transcriptionally transiently
Tagcloud (Difference) ?		3gamma 3zeta abundant actual anions check destabilized glycerol governing hsp20 huge hypothesized inorganic interaction monomeric obscure participating partners phosphate phosphointeractome phosphorylated physiological physiologically presumably pyrophosphate sulfate theoretically undergoes	accordingly ala antiestrogens antiprogestins cdk2 cdks coactivators copurified cos deregulation disrupted g2 insensitive keys lysates pr probed progesterone progestin prs roscovitine s345a ser345 sp1 synchronized t47d talk transcriptionally transiently
Tagcloud (Intersection) ?