HSPB6 and HSPB8

Number of citations of the paper that reports this interaction (PubMedID 16225851)
0

Data Source:
HPRD (two hybrid, in vivo)

		HSPB6	HSPB8
Description		heat shock protein family B (small) member 6	heat shock protein family B (small) member 8
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol Protein Folding Chaperone Complex
	Molecular Function	Structural Constituent Of Eye Lens Protein Kinase Binding Protein Homodimerization Activity Protein Folding Chaperone Unfolded Protein Binding Protein-folding Chaperone Binding	Protein Kinase Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Folding Response To Heat Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis	Cellular Response To Unfolded Protein Positive Regulation Of Aggrephagy
Pathways			HSF1-dependent transactivation
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Distal hereditary motor neuropathies (dHMN)
GWAS		Brain morphology (MOSTest) ( 32665545)	Metabolite levels ( 23823483) PR interval in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes		6 interacting genes: BECN1 CRYAB HSPB8 SNCA YWHAG YWHAZ	21 interacting genes: ATOSB ATXN7L2 BAG3 CATSPERT CRYAB CSNK2A1 DUSP12 HSPB1 HSPB2 HSPB3 HSPB6 HSPB7 MAPK3 MISP PRKCA QRICH1 RPIA SLC16A5 SNCA SOCS7 TRAPPC6A
Entrez ID		126393	26353
HPRD ID		08130	06420
Ensembl ID		ENSG00000004776	ENSG00000152137
Uniprot IDs		O14558 V9HWB6	Q9UJY1
PDB IDs		4JUS 4JUT 5LTW 5LU1 5LU2 5LUM 5OK9 5OKF	8S7A
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Protein Sequestering Activity Cellular Response To Glucose Starvation Identical Protein Binding Response To Iron(II) Ion Regulation Of Protein Stability Regulation Of Lysosome Organization Cellular Response To Copper Ion Cellular Response To Starvation Protein Targeting Response To Stress Protein Domain Specific Binding Response To Starvation MAPK Cascade Response To Iron Ion Response To Copper Ion Cellular Response To Nutrient Levels Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Oxidative Stress Regulation Of Autophagy Protein Localization To Lysosome Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling TORC1 Signaling Lysosome Organization Regulation Of Vacuole Organization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Organelle Localization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission TOR Signaling Cellular Response To Aluminum Ion Protein Localization To Vacuole Response To Nutrient Levels Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Macroautophagy Response To Hydrogen Peroxide Negative Regulation Of Metabolic Process Negative Regulation Of Autophagy Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Catabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process	Response To Unfolded Protein Protein Refolding Response To Heat Protein Folding Response To Temperature Stimulus Structural Constituent Of Eye Lens Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Unfolded Protein Binding Positive Regulation Of Aggrephagy Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Stability Regulation Of Autophagy Response To Stress Contractile Muscle Fiber Protein Transport Along Microtubule Protein Stabilization Positive Regulation Of Macroautophagy Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Protein Catabolic Process Apoptotic Process Z Disc Negative Regulation Of Protein Metabolic Process Cell Death Programmed Cell Death Aggresome Negative Regulation Of Striated Muscle Cell Apoptotic Process Cytoplasm Positive Regulation Of Autophagy Positive Regulation Of Angiogenesis Negative Regulation Of Protein Kinase C Signaling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ribose-5-phosphate Isomerase Activity Positive Regulation Of Vasculature Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Macroautophagy Response To Mechanical Stimulus
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