DYNLL2 and STXBP4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)

		DYNLL2	STXBP4
Description		dynein light chain LC8-type 2	syntaxin binding protein 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse	Cytoplasm Cytoplasmic Vesicle Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding	Protein Binding Syntaxin Binding
	Biological Process	Microtubule-based Process	Protein Targeting Response To Stress DNA Damage Response Insulin Receptor Signaling Pathway Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Keratinocyte Proliferation Protein Stabilization Regulation Of Transport Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Type II Interferon Positive Regulation Of Cell Cycle G1/S Phase Transition
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Intrinsic epigenetic age acceleration ( 29374233) Menarche (age at onset) ( 25231870) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Night sleep phenotypes ( 27126917) Plateletcrit ( 32888494) Systolic blood pressure ( 34074324) Zinc levels ( 26025379)
Interacting Genes		30 interacting genes: BMF C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 IHO1 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 REDIC1 SKAP1 SMCP SPAG8 THAP10 TPPP XIAP ZAR1	5 interacting genes: ATN1 ENKD1 KLHL42 STX4 TRIM54
Entrez ID		140735	252983
HPRD ID		06489	18127
Ensembl ID		ENSG00000264364	ENSG00000166263
Uniprot IDs		Q96FJ2	B5MCT9 Q6ZWJ1
PDB IDs		2XQQ 3P8M 4D07 7CNU	2YSG
Enriched GO Terms of Interacting Partners?		Microtubule Binding	9+0 Non-motile Cilium Microtubule Associated Complex Microtubule Sphingomyelin Phosphodiesterase Activator Activity Myosin V Complex Positive Regulation Of Eosinophil Degranulation Storage Vacuole Cytoskeleton Neuron Projection Membrane Lateral Loop
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