DYNLL2 and MSI2

		DYNLL2	MSI2
Description		dynein light chain LC8-type 2	musashi RNA binding protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Poly(U) RNA Binding Identical Protein Binding
	Biological Process	Microtubule-based Process	Regulation Of Translation Central Nervous System Development Stem Cell Development
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	RHOBTB2 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Birth weight ( 31043758) Chronotype ( 30696823) Coronary artery calcification ( 23870195) Decreased low contrast letter acuity in multiple sclerosis ( 31289819) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Freckles ( 29895819) Height ( 31562340) Male-pattern baldness ( 29146897 27182965) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Pulse pressure ( 30224653) Rapid automised naming of pictures ( 30741946) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) White blood cell count ( 32888494)
Interacting Genes		30 interacting genes: BMF C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 IHO1 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 REDIC1 SKAP1 SMCP SPAG8 THAP10 TPPP XIAP ZAR1	74 interacting genes: DMRTB1 EIF3E GRB2 HNRNPH1 HNRNPH2 KHDRBS2 MBNL2 MEOX2 MIR1-1 MIR106A MIR106B MIR10B MIR128-1 MIR128-2 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29B2 MIR29C MIR34A MIR34B MIR34C MIR363 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I QKI RBFOX2 RBPMS SRPK2
Entrez ID		140735	124540
HPRD ID		06489	07438
Ensembl ID		ENSG00000264364	ENSG00000153944
Uniprot IDs		Q96FJ2	B4DHE8 Q96DH6
PDB IDs		2XQQ 3P8M 4D07 7CNU	6C8U 6DBP 6NTY
Enriched GO Terms of Interacting Partners?		Microtubule Binding	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Negative Regulation Of Cell Migration Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of RNA Stability Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Space Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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