MSI2 and MBNL2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		MSI2	MBNL2
Description		musashi RNA binding protein 2	muscleblind like splicing regulator 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Poly(U) RNA Binding Identical Protein Binding	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Translation Central Nervous System Development Stem Cell Development	MRNA Processing RNA Splicing Regulation Of RNA Splicing
Pathways		RHOBTB2 GTPase cycle
Drugs
Diseases
GWAS		Birth weight ( 31043758) Chronotype ( 30696823) Coronary artery calcification ( 23870195) Decreased low contrast letter acuity in multiple sclerosis ( 31289819) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Freckles ( 29895819) Height ( 31562340) Male-pattern baldness ( 29146897 27182965) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Pulse pressure ( 30224653) Rapid automised naming of pictures ( 30741946) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) White blood cell count ( 32888494)	Alcoholism (alcohol dependence factor score) ( 21529783) Alcoholism (alcohol use disorder factor score) ( 21529783) Diastolic blood pressure ( 30224653) Energy expenditure (24h) ( 28476931) Lung function in heavy smokers (high FEV1 vs average FEV1) ( 26423011) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet reactivity in response to clopidogrel treatment ( 32472697) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		74 interacting genes: DMRTB1 EIF3E GRB2 HNRNPH1 HNRNPH2 KHDRBS2 MBNL2 MEOX2 MIR1-1 MIR106A MIR106B MIR10B MIR128-1 MIR128-2 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29B1 MIR29B2 MIR29C MIR34A MIR34B MIR34C MIR363 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I QKI RBFOX2 RBPMS SRPK2	5 interacting genes: MSI2 QKI RBPMS SNRPA TIAL1
Entrez ID		124540	10150
HPRD ID		07438	09543
Ensembl ID		ENSG00000153944	ENSG00000139793
Uniprot IDs		B4DHE8 Q96DH6	A0A7P0T9I3 A0A994J506 A0A994J509 A2A3S3 Q5VZF2
PDB IDs		6C8U 6DBP 6NTY	2E5S 2RPP
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization Regulation Of Macromolecule Metabolic Process RNA Destabilization Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Negative Regulation Of Cell Migration Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of RNA Stability Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Extracellular Space Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Nucleic Acid Binding Cytoplasmic Stress Granule RNA Binding MRNA 3'-UTR Binding MRNA Binding Internal N(7)-methylguanine-containing RNA Reader Activity Regulation Of MRNA Splicing, Via Spliceosome Myofibroblast Contraction Regulation Of MRNA Processing Negative Regulation Of MiRNA Catabolic Process Spliceosomal SnRNP Complex RNA Processing Protein-RNA Adaptor Activity Regulation Of RNA Splicing Spliceosome-depend Formation Of Circular RNA MRNA CDS Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Negative Regulation Of 3'-UTR-mediated MRNA Stabilization U1 SnRNA Binding U1 SnRNP Binding Microglia Differentiation Negative Regulation Of Macrophage Differentiation Transcription Coactivator Activity Vascular Associated Smooth Muscle Cell Differentiation Cytolytic Granule Positive Regulation Of MiRNA-mediated Gene Silencing Regulation Of MRNA Metabolic Process Intracellular MRNA Localization Pre-mRNA Intronic Binding RNA Splicing U1 SnRNP Regulation Of Translation Positive Regulation Of Myelination Pre-mRNA Binding MRNA Processing Positive Regulation Of Hippo Signaling Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Oligodendrocyte Differentiation Poly(U) RNA Binding Regulation Of Macrophage Differentiation SMAD Protein Signal Transduction Identical Protein Binding Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Smooth Muscle Cell Differentiation Regulation Of Astrocyte Differentiation Stress Granule Assembly RNA Localization Regulation Of Cholesterol Biosynthetic Process
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