IL33

Gene Name		interleukin 33
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Chromosome Transport Vesicle
	Molecular Function	Cytokine Activity Protein Binding
	Biological Process	Negative Regulation Of Leukocyte Migration Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Type 2 Immune Response Transcription, DNA-templated Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Type 2 Immune Response Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Inflammatory Response Positive Regulation Of Immunoglobulin Secretion Negative Regulation Of Immunoglobulin Secretion Positive Regulation Of Chemokine Secretion Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Asthma ( 21804549 20860503) Endometriosis ( 23472165) Periodontal microbiota ( 22699663)
Protein-protein Interactions		5 interactors: CASP1 CRMP1 HIST2H2AA3 HIST2H2BE IL1RL1
Entrez ID		90865
HPRD ID		12275
Ensembl ID		ENSG00000137033
Uniprot IDs		O95760
PDB IDs		2KLL 4KC3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytokine Secretion Interleukin-33-mediated Signaling Pathway Regulation Of Cytokine Secretion Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Protein Secretion Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Regulation Of Inflammatory Response Immune Response Negative Regulation Of T-helper 1 Type Immune Response Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Secretion Positive Regulation Of Chemokine Secretion Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Macrophage Activation Regulation Of Protein Secretion Interleukin-1 Beta Production Positive Regulation Of Interleukin-5 Production Innate Immune Response In Mucosa Response To Bacterium Response To External Stimulus Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Secretion Regulation Of Macrophage Activation Regulation Of Interleukin-5 Production Response To ATP Antibacterial Humoral Response Antimicrobial Humoral Response Positive Regulation Of Interleukin-1 Beta Production Regulation Of Protein Transport Immune System Process Positive Regulation Of Interleukin-1 Production Mucosal Immune Response Regulation Of Secretion Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Interferon-gamma Production Regulation Of Establishment Of Protein Localization Negative Regulation Of Adaptive Immune Response Membrane Hyperpolarization Pyrimidine Nucleobase Metabolic Process Toxin Transport Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Other Organism Positive Regulation Of Chemokine Production Positive Regulation Of Transport
Tagcloud ?		10ko acp5 aia arthritic arthritis autoinflammatory blockade casp1 driven erosions ex exogenous focal hence histological histopathology il1b inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate