IL33

Description		interleukin 33
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Transport Vesicle Cytoplasmic Vesicle
	Molecular Function	Interleukin-33 Receptor Binding Cytokine Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Macrophage Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Negative Regulation Of Immunoglobulin Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Leukocyte Migration Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Type 2 Immune Response Protein Import Into Nucleus Response To Wounding Positive Regulation Of Cellular Defense Response Gene Expression Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Gene Expression Macrophage Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Interleukin-33-mediated Signaling Pathway Type 2 Immune Response Positive Regulation Of Macrophage Activation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Microglial Cell Proliferation Inflammatory Response To Wounding Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Negative Regulation Of Macrophage Proliferation Antibacterial Innate Immune Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		PIP3 activates AKT signaling Ub-specific processing proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310 30013184) Allergy ( 27182965) Asthma ( 21804549 34103634 32296059 31959851 31619474 31361310 30929738 29785011 27182965 20860503 29273806) Asthma (adult onset) ( 30929738 31036433) Asthma (childhood onset) ( 24241537 29273806 30929738 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Childhood asthma with severe exacerbations ( 33328473) Chronic rhinosinusitis ( 30643255) Eczema ( 31361310) Endometriosis ( 23472165) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Periodontal microbiota ( 22699663) Self-reported allergy ( 23817569) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Small cell lung carcinoma ( 28604730)
Interacting Genes		6 interacting genes: CASP1 CRMP1 H2AC18 H2BC21 IL1RL1 MDM2
Entrez ID		90865
HPRD ID		12275
Ensembl ID		ENSG00000137033
Uniprot IDs		O95760
PDB IDs		2KLL 4KC3
Enriched GO Terms of Interacting Partners?		AIM2 Inflammasome Complex IPAF Inflammasome Complex AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Negative Regulation Of Neuron Projection Development Response To Vitamin B1 Response To Water-immersion Restraint Stress Response To Formaldehyde Cellular Response To Vitamin B1 Cellular Response To Actinomycin D Nucleosome Structural Constituent Of Chromatin Interleukin-33 Binding Interleukin-33 Receptor Activity Positive Regulation Of Inflammatory Response NEDD8 Ligase Activity Response To Actinomycin D Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cytokine Precursor Processing Negative Regulation Of Cell Projection Organization Cellular Response To UV-C NLRP1 Inflammasome Complex Dihydropyrimidinase Activity Receptor Serine/threonine Kinase Binding Interleukin-1 Receptor Activity
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