IL33 and IL1RL1

Number of citations of the paper that reports this interaction (PubMedID 19559631)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		IL33	IL1RL1
Description		interleukin 33	interleukin 1 receptor like 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Chromosome Cytoplasm Transport Vesicle Cytoplasmic Vesicle	Extracellular Region Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Interleukin-33 Receptor Binding Cytokine Activity Protein Binding	Interleukin-33 Binding Interleukin-33 Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Protein Binding Hydrolase Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Macrophage Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Negative Regulation Of Immunoglobulin Production Positive Regulation Of Immunoglobulin Production Negative Regulation Of Leukocyte Migration Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Type 2 Immune Response Protein Import Into Nucleus Response To Wounding Positive Regulation Of Cellular Defense Response Gene Expression Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Gene Expression Macrophage Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Interleukin-33-mediated Signaling Pathway Type 2 Immune Response Positive Regulation Of Macrophage Activation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Positive Regulation Of Multicellular Organismal Process Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Microglial Cell Proliferation Inflammatory Response To Wounding Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Negative Regulation Of Macrophage Proliferation Antibacterial Innate Immune Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Negative Regulation Of T-helper 1 Type Immune Response Inflammatory Response Immune Response Signal Transduction Response To Wounding Macrophage Differentiation Negative Regulation Of Type II Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Inflammatory Response
Pathways		PIP3 activates AKT signaling Ub-specific processing proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling	PIP3 activates AKT signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-33 signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310 30013184) Allergy ( 27182965) Asthma ( 21804549 34103634 32296059 31959851 31619474 31361310 30929738 29785011 27182965 20860503 29273806) Asthma (adult onset) ( 30929738 31036433) Asthma (childhood onset) ( 24241537 29273806 30929738 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Childhood asthma with severe exacerbations ( 33328473) Chronic rhinosinusitis ( 30643255) Eczema ( 31361310) Endometriosis ( 23472165) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Periodontal microbiota ( 22699663) Self-reported allergy ( 23817569) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Small cell lung carcinoma ( 28604730)	Adult asthma ( 30578877) Allergic disease (asthma, hay fever or eczema) ( 29785011) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 27182965 30929738 29273806 26620591 31361310 31619474 34103634 21804549 23028483 32296059 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 30929738 29273806 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879 23042114) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Celiac disease ( 18311140 20190752) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 21102463 28067908) Delirium ( 29631748) Eosinophil count ( 29403010 32888494 19198610) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Inflammatory bowel disease ( 28067908 23128233) Lung function (FEV1/FVC) ( 30804560) Nasal polyps ( 30643255) Neutrophil percentage of white cells ( 32888494) Primary biliary cholangitis ( 26394269) Self-reported allergy ( 23817569) Serum protein levels (sST2) ( 23999434) Waist circumference ( 23966867)
Interacting Genes		6 interacting genes: CASP1 CRMP1 H2AC18 H2BC21 IL1RL1 MDM2	18 interacting genes: APP ASGR2 CLEC12B CLEC2D CLEC7A CREB3L1 GPR152 GPR42 HRAS IL33 MCFD2 MYD88 SIGLEC12 SLC38A1 TIRAP TMED1 TSPAN18 YIPF6
Entrez ID		90865	9173
HPRD ID		12275	03123
Ensembl ID		ENSG00000137033	ENSG00000115602
Uniprot IDs		O95760	Q01638
PDB IDs		2KLL 4KC3	4KC3
Enriched GO Terms of Interacting Partners?		AIM2 Inflammasome Complex IPAF Inflammasome Complex AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Negative Regulation Of Neuron Projection Development Response To Vitamin B1 Response To Water-immersion Restraint Stress Response To Formaldehyde Cellular Response To Vitamin B1 Cellular Response To Actinomycin D Nucleosome Structural Constituent Of Chromatin Interleukin-33 Binding Interleukin-33 Receptor Activity Positive Regulation Of Inflammatory Response NEDD8 Ligase Activity Response To Actinomycin D Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cytokine Precursor Processing Negative Regulation Of Cell Projection Organization Cellular Response To UV-C NLRP1 Inflammasome Complex Dihydropyrimidinase Activity Receptor Serine/threonine Kinase Binding Interleukin-1 Receptor Activity	Positive Regulation Of Chemokine Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Carbohydrate Binding Vesicle-mediated Transport Defense Response To Protozoan Positive Regulation Of JNK Cascade Response To Protozoan Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Type II Interferon Production Response To Molecule Of Fungal Origin Immune Response-regulating Cell Surface Receptor Signaling Pathway Defense Response To Other Organism Positive Regulation Of Cytokine Production Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of JNK Cascade Positive Regulation Of Interleukin-23 Production Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-8 Production Plasma Membrane Regulation Of Interleukin-23 Production Innate Immune Response Regulation Of Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Interleukin-1 Production Defense Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Type II Interferon Production Immune Response-regulating Signaling Pathway Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Regulation Of Leukocyte Migration Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Innate Immune Response Response To Yeast Positive Regulation Of MAPK Cascade Positive Regulation Of Defense Response Regulation Of Interleukin-8 Production Defense Response To Symbiont MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress
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