CRH and CRHR2

Number of citations of the paper that reports this interaction (PubMedID 8243338)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		CRH	CRHR2
Description		corticotropin releasing hormone	corticotropin releasing hormone receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuronal Cell Body Varicosity Perikaryon Synapse Neuronal Dense Core Vesicle Lumen	Plasma Membrane Membrane Dendrite Axon Terminus
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Corticotropin-releasing Hormone Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity
	Biological Process	Synaptic Transmission, Dopaminergic Negative Regulation Of Systemic Arterial Blood Pressure Glucocorticoid Biosynthetic Process Inflammatory Response Signal Transduction Chemical Synaptic Transmission Female Pregnancy Parturition Learning Or Memory Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Associative Learning Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Regulation Of Serotonin Secretion Diterpenoid Metabolic Process Hypothalamus Development Lung Development Adrenal Gland Development Negative Regulation Of Epinephrine Secretion Negative Regulation Of Luteinizing Hormone Secretion Locomotory Exploration Behavior Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Immobilization Stress Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Estrogen Response To Ethanol Response To Ether Response To Pain Monoatomic Ion Homeostasis Neuron Apoptotic Process Response To Corticosterone Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Long-term Synaptic Potentiation Positive Regulation Of Digestive System Process Negative Regulation Of Glucagon Secretion Cellular Response To Cocaine Cellular Response To Dexamethasone Stimulus Positive Regulation Of Calcium Ion Import Response To Alcohol Positive Regulation Of CAMP/PKA Signal Transduction Response To Aldosterone Regulation Of NMDA Receptor Activity Positive Regulation Of Corticosterone Secretion Positive Regulation Of Behavioral Fear Response	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events MECP2 regulates transcription of neuronal ligands	G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin
Drugs		Corticotropin D-Phenylalanine 2-aminoisobutyric acid
Diseases
GWAS		Adult body size ( 32376654) Coronary heart disease event reduction (statin therapy interaction) ( 22666496)	Type 2 diabetes ( 24509480 30297969)
Interacting Genes		13 interacting genes: CRHR1 CRHR2 CYSRT1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP5-9 KRTAP9-3 MDFI NBPF19 NOTCH2NLA	7 interacting genes: APP CRH GPR35 MALL UCN UCN2 UCN3
Entrez ID		1392	1395
HPRD ID		07172	03614
Ensembl ID		ENSG00000147571	ENSG00000106113
Uniprot IDs		A0A0S2Z478 P06850	A0A090N7T4 Q13324
PDB IDs		1GO9 1GOE 3EHT 3EHU 6P9X	3N93 3N95 3N96 6PB1 7TRY 7TS0
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Corticotropin-releasing Hormone Receptor Activity Corticotrophin-releasing Factor Receptor Activity Cellular Response To Corticotropin-releasing Hormone Stimulus Epidermis Development G Protein-coupled Peptide Receptor Activity	Corticotropin-releasing Hormone Receptor 2 Binding Varicosity Positive Regulation Of CAMP/PKA Signal Transduction Hormone Activity Corticotropin-releasing Hormone Receptor Binding Regulation Of CAMP/PKA Signal Transduction Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Calcium Ion Transport Positive Regulation Of Corticotropin Secretion G Protein-coupled Receptor Binding Positive Regulation Of Behavioral Fear Response Regulation Of Corticotropin Secretion Positive Regulation Of Fear Response Associative Learning G Protein-coupled Receptor Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Signaling Receptor Binding Regulation Of Monoatomic Ion Transport Response To Corticosterone Response To Glucocorticoid Response To Pain Perikaryon Hormone-mediated Signaling Pathway Positive Regulation Of Hormone Secretion Response To Auditory Stimulus Response To Corticosteroid Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Response To Immobilization Stress Positive Regulation Of Calcium Ion Import Positive Regulation Of Behavior Digestion Neuropeptide Hormone Activity Regulation Of Peptide Hormone Secretion Response To Steroid Hormone Response To Mineralocorticoid Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Calcium Ion Import Negative Regulation Of Blood Pressure Learning Or Memory Positive Regulation Of Secretion By Cell Regulation Of Transport Axon Terminus Cognition Positive Regulation Of Establishment Of Protein Localization
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