CRH and CRHR2

Number of citations of the paper that reports this interaction (PMID 8243338)
48

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		CRH	CRHR2
Gene Name		corticotropin releasing hormone	corticotropin releasing hormone receptor 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Varicosity Perikaryon	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Corticotropin-releasing Hormone Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	Hormone Activity Protein Binding Corticotrophin-releasing Factor Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Glucocorticoid Biosynthetic Process Inflammatory Response Signal Transduction Synaptic Transmission Female Pregnancy Parturition Learning Or Memory Long-term Memory Feeding Behavior Positive Regulation Of Cell Proliferation Associative Learning Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Positive Regulation Of Cell Death Regulation Of Serotonin Secretion Diterpenoid Metabolic Process Hypothalamus Development Lung Development Adrenal Gland Development Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Epinephrine Secretion Negative Regulation Of Luteinizing Hormone Secretion Locomotory Exploration Behavior Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Immobilization Stress Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Drug Response To Estrogen Response To Ethanol Response To Ether Negative Regulation Of Blood Pressure Response To Pain Ion Homeostasis Response To Corticosterone Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Response To Electrical Stimulus Long-term Synaptic Potentiation Positive Regulation Of Digestive System Process Negative Regulation Of Cell Death Negative Regulation Of Glucagon Secretion Cellular Response To Cocaine Cellular Response To Dexamethasone Stimulus Positive Regulation Of Calcium Ion Import Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Corticosterone Secretion Positive Regulation Of Behavioral Fear Response	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Angiogenesis Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs		Corticotropin D-Phenylalanine Alpha-Aminoisobutyric Acid
Diseases
GWAS		Response to statin therapy ( 22666496)
Protein-Protein Interactions		3 interactors: CRHR1 CRHR2 KRT31	5 interactors: APP CRH UCN UCN2 UCN3
Entrez ID		1392	1395
HPRD ID		07172	03614
Ensembl ID		ENSG00000147571
Uniprot IDs		P06850	B2R967 B3SXS6 B3SXT0 Q13324
PDB IDs		3EHT 3EHU	3N93 3N95 3N96
Enriched GO Terms of Interacting Partners?		Cellular Response To Corticotropin-releasing Hormone Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger General Adaptation Syndrome, Behavioral Process Corticotropin Secretion General Adaptation Syndrome Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Corticosterone Secretion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Epinephrine Secretion Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Feeding Behavior Negative Regulation Of CAMP-mediated Signaling Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Locomotory Exploration Behavior Behavioral Response To Ethanol Positive Regulation Of Mast Cell Degranulation Regulation Of Feeding Behavior Positive Regulation Of CAMP-mediated Signaling Behavioral Response To Cocaine Positive Regulation Of Mast Cell Activation Cellular Response To Hormone Stimulus Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Parturition Negative Regulation Of Cation Channel Activity Positive Regulation Of Regulated Secretory Pathway Regulation Of Voltage-gated Calcium Channel Activity Behavioral Response To Pain Regulation Of CAMP-mediated Signaling Response To Immobilization Stress Hypothalamus Development Regulation Of Mast Cell Degranulation Exploration Behavior Response To Organonitrogen Compound Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Regulation Of Mast Cell Activation Response To Hormone Regulation Of Regulated Secretory Pathway Adrenal Gland Development Response To Pain Fear Response Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Response To Electrical Stimulus Positive Regulation Of Lyase Activity	Response To Immobilization Stress Response To Glucocorticoid Response To Corticosteroid Regulation Of Hormone Secretion Positive Regulation Of Corticotropin Secretion Negative Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Hormone Secretion Regulation Of Corticotropin Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Associative Learning Feeding Behavior Positive Regulation Of Behavioral Fear Response Negative Regulation Of Gonadotropin Secretion Response To Steroid Hormone Positive Regulation Of Hormone Secretion Digestion Learning Regulation Of Secretion Positive Regulation Of Calcium Ion Import Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion Regulation Of Peptide Hormone Secretion Response To Lipid Regulation Of Calcium Ion Import Response To Organic Cyclic Compound Response To Hormone Learning Or Memory Regulation Of Cellular Localization Cognition Response To Corticosterone Response To Abiotic Stimulus Positive Regulation Of Secretion Response To Mineralocorticoid Response To Pain Regulation Of Signaling Negative Regulation Of Blood Pressure Negative Regulation Of Transport Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Nutrient Levels Positive Regulation Of CAMP Biosynthetic Process Single-organism Behavior Response To Stress Response To Extracellular Stimulus Positive Regulation Of Insulin Secretion Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Cyclic Nucleotide Metabolic Process
Tagcloud ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary pomc proopiomelanocortin releasing steroid superfamily transformants transiently	amygdala cns corticosterone corticotropin crf2 disparity drinking f2 gs inbred inp ip lowered maps minute nonpreferring np polymorphism preference preferring qtl releasing restraint screen trait ucns untranslated urocortins
Tagcloud (Difference) ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary pomc proopiomelanocortin steroid superfamily transformants transiently	amygdala cns corticosterone crf2 disparity drinking f2 gs inbred inp ip lowered maps minute nonpreferring np polymorphism preference preferring qtl restraint screen trait ucns untranslated urocortins
Tagcloud (Intersection) ?		corticotropin releasing