CRH and KRTAP1-5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRH	KRTAP1-5
Description		corticotropin releasing hormone	keratin associated protein 1-5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuronal Cell Body Varicosity Perikaryon Synapse Neuronal Dense Core Vesicle Lumen	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Corticotropin-releasing Hormone Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	Protein Binding
	Biological Process	Synaptic Transmission, Dopaminergic Negative Regulation Of Systemic Arterial Blood Pressure Glucocorticoid Biosynthetic Process Inflammatory Response Signal Transduction Chemical Synaptic Transmission Female Pregnancy Parturition Learning Or Memory Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Associative Learning Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Regulation Of Serotonin Secretion Diterpenoid Metabolic Process Hypothalamus Development Lung Development Adrenal Gland Development Negative Regulation Of Epinephrine Secretion Negative Regulation Of Luteinizing Hormone Secretion Locomotory Exploration Behavior Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Immobilization Stress Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Estrogen Response To Ethanol Response To Ether Response To Pain Monoatomic Ion Homeostasis Neuron Apoptotic Process Response To Corticosterone Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Long-term Synaptic Potentiation Positive Regulation Of Digestive System Process Negative Regulation Of Glucagon Secretion Cellular Response To Cocaine Cellular Response To Dexamethasone Stimulus Positive Regulation Of Calcium Ion Import Response To Alcohol Positive Regulation Of CAMP/PKA Signal Transduction Response To Aldosterone Regulation Of NMDA Receptor Activity Positive Regulation Of Corticosterone Secretion Positive Regulation Of Behavioral Fear Response
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events MECP2 regulates transcription of neuronal ligands	Keratinization
Drugs		Corticotropin D-Phenylalanine 2-aminoisobutyric acid
Diseases
GWAS		Adult body size ( 32376654) Coronary heart disease event reduction (statin therapy interaction) ( 22666496)
Interacting Genes		13 interacting genes: CRHR1 CRHR2 CYSRT1 KRT31 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP5-9 KRTAP9-3 MDFI NBPF19 NOTCH2NLA	47 interacting genes: ADAMTSL4 AQP1 CATSPER1 CREB5 CRH CYSRT1 DMRT3 FAM124B GRN GUCD1 HOXA1 HOXB9 KPRP KRTAP10-1 KRTAP10-5 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP9-2 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3D LCE3E LCE4A LCE5A NMU NUFIP2 OTX1 PLSCR4 SDCBP SHFL SMCP WNT11 YY1
Entrez ID		1392	83895
HPRD ID		07172	12306
Ensembl ID		ENSG00000147571	ENSG00000221852
Uniprot IDs		A0A0S2Z478 P06850	Q9BYS1
PDB IDs		1GO9 1GOE 3EHT 3EHU 6P9X
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Corticotropin-releasing Hormone Receptor Activity Corticotrophin-releasing Factor Receptor Activity Cellular Response To Corticotropin-releasing Hormone Stimulus Epidermis Development G Protein-coupled Peptide Receptor Activity	Keratinization Epidermis Development Tissue Development Intermediate Filament Keratin Filament Hair Cycle Identical Protein Binding Developmental Process Protein Binding Positive Regulation Of Digestive System Process
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