CRH

Gene Name		corticotropin releasing hormone
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Varicosity Perikaryon
	Molecular Function	Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Corticotropin-releasing Hormone Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Glucocorticoid Biosynthetic Process Inflammatory Response Signal Transduction Synaptic Transmission Female Pregnancy Parturition Learning Or Memory Long-term Memory Feeding Behavior Positive Regulation Of Cell Proliferation Associative Learning Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Positive Regulation Of Cell Death Regulation Of Serotonin Secretion Diterpenoid Metabolic Process Hypothalamus Development Lung Development Adrenal Gland Development Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Epinephrine Secretion Negative Regulation Of Luteinizing Hormone Secretion Locomotory Exploration Behavior Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Immobilization Stress Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Drug Response To Estrogen Response To Ethanol Response To Ether Negative Regulation Of Blood Pressure Response To Pain Ion Homeostasis Response To Corticosterone Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Response To Electrical Stimulus Long-term Synaptic Potentiation Positive Regulation Of Digestive System Process Negative Regulation Of Cell Death Negative Regulation Of Glucagon Secretion Cellular Response To Cocaine Cellular Response To Dexamethasone Stimulus Positive Regulation Of Calcium Ion Import Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Corticosterone Secretion Positive Regulation Of Behavioral Fear Response
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs		Corticotropin D-Phenylalanine Alpha-Aminoisobutyric Acid
Diseases
GWAS		Response to statin therapy ( 22666496)
Protein-protein Interactions		3 interactors: CRHR1 CRHR2 KRT31
Entrez ID		1392
HPRD ID		07172
Ensembl ID		ENSG00000147571
Uniprot IDs		P06850
PDB IDs		3EHT 3EHU
Enriched GO Terms of Interacting Partners?		Cellular Response To Corticotropin-releasing Hormone Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger General Adaptation Syndrome, Behavioral Process Corticotropin Secretion General Adaptation Syndrome Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Corticosterone Secretion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Epinephrine Secretion Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Feeding Behavior Negative Regulation Of CAMP-mediated Signaling Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Locomotory Exploration Behavior Behavioral Response To Ethanol Positive Regulation Of Mast Cell Degranulation Regulation Of Feeding Behavior Positive Regulation Of CAMP-mediated Signaling Behavioral Response To Cocaine Positive Regulation Of Mast Cell Activation Cellular Response To Hormone Stimulus Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Parturition Negative Regulation Of Cation Channel Activity Positive Regulation Of Regulated Secretory Pathway Regulation Of Voltage-gated Calcium Channel Activity Behavioral Response To Pain Regulation Of CAMP-mediated Signaling Response To Immobilization Stress Hypothalamus Development Regulation Of Mast Cell Degranulation Exploration Behavior Response To Organonitrogen Compound Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Regulation Of Mast Cell Activation Response To Hormone Regulation Of Regulated Secretory Pathway Adrenal Gland Development Response To Pain Fear Response Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Response To Electrical Stimulus Positive Regulation Of Lyase Activity
Tagcloud ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary pomc proopiomelanocortin releasing steroid superfamily transformants transiently