CRH and CRHR1

Number of citations of the paper that reports this interaction (PMID 9178757)
10

Data Source:
HPRD (in vivo)

		CRH	CRHR1
Gene Name		corticotropin releasing hormone	corticotropin releasing hormone receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Varicosity Perikaryon	Multivesicular Body Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Dendrite Intrinsic Component Of Plasma Membrane Vesicle Neuronal Cell Body Apical Part Of Cell
	Molecular Function	Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Corticotropin-releasing Hormone Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	G-protein Alpha-subunit Binding Protein Binding Corticotrophin-releasing Factor Receptor Activity Protein Complex Binding Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Glucocorticoid Biosynthetic Process Inflammatory Response Signal Transduction Synaptic Transmission Female Pregnancy Parturition Learning Or Memory Long-term Memory Feeding Behavior Positive Regulation Of Cell Proliferation Associative Learning Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Positive Regulation Of Cell Death Regulation Of Serotonin Secretion Diterpenoid Metabolic Process Hypothalamus Development Lung Development Adrenal Gland Development Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Epinephrine Secretion Negative Regulation Of Luteinizing Hormone Secretion Locomotory Exploration Behavior Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Immobilization Stress Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Drug Response To Estrogen Response To Ethanol Response To Ether Negative Regulation Of Blood Pressure Response To Pain Ion Homeostasis Response To Corticosterone Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Response To Electrical Stimulus Long-term Synaptic Potentiation Positive Regulation Of Digestive System Process Negative Regulation Of Cell Death Negative Regulation Of Glucagon Secretion Cellular Response To Cocaine Cellular Response To Dexamethasone Stimulus Positive Regulation Of Calcium Ion Import Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Corticosterone Secretion Positive Regulation Of Behavioral Fear Response	Response To Hypoxia Immune Response Activation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Female Pregnancy Parturition Memory Visual Learning Hormone-mediated Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Hypothalamus Development Adrenal Gland Development Epithelial Cell Differentiation Negative Regulation Of Epinephrine Secretion Locomotory Exploration Behavior Response To Immobilization Stress Fear Response Positive Regulation Of Mast Cell Degranulation Behavioral Response To Cocaine Behavioral Response To Ethanol Behavioral Response To Pain Corticotropin Secretion Response To Electrical Stimulus General Adaptation Syndrome, Behavioral Process Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Neuron Death Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Feeding Behavior Regulation Of Corticosterone Secretion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs		Corticotropin D-Phenylalanine Alpha-Aminoisobutyric Acid
Diseases
GWAS		Response to statin therapy ( 22666496)	Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Head circumference (infant) ( 22504419) Intracranial volume ( 22504418)
Protein-Protein Interactions		3 interactors: CRHR1 CRHR2 KRT31	9 interactors: CALM1 CRH GNAI1 GNAO1 GNAQ GNAS SRPK1 UCN UCN3
Entrez ID		1392	1394
HPRD ID		07172	08830
Ensembl ID		ENSG00000147571	ENSG00000120088
Uniprot IDs		P06850	B3TIK8 G3CIS4 P34998
PDB IDs		3EHT 3EHU	2L27 3EHS 3EHT 3EHU 4K5Y
Enriched GO Terms of Interacting Partners?		Cellular Response To Corticotropin-releasing Hormone Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger General Adaptation Syndrome, Behavioral Process Corticotropin Secretion General Adaptation Syndrome Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Corticosterone Secretion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Epinephrine Secretion Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Feeding Behavior Negative Regulation Of CAMP-mediated Signaling Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Locomotory Exploration Behavior Behavioral Response To Ethanol Positive Regulation Of Mast Cell Degranulation Regulation Of Feeding Behavior Positive Regulation Of CAMP-mediated Signaling Behavioral Response To Cocaine Positive Regulation Of Mast Cell Activation Cellular Response To Hormone Stimulus Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Parturition Negative Regulation Of Cation Channel Activity Positive Regulation Of Regulated Secretory Pathway Regulation Of Voltage-gated Calcium Channel Activity Behavioral Response To Pain Regulation Of CAMP-mediated Signaling Response To Immobilization Stress Hypothalamus Development Regulation Of Mast Cell Degranulation Exploration Behavior Response To Organonitrogen Compound Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Regulation Of Mast Cell Activation Response To Hormone Regulation Of Regulated Secretory Pathway Adrenal Gland Development Response To Pain Fear Response Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Response To Electrical Stimulus Positive Regulation Of Lyase Activity	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Response To Stress Regulation Of CAMP Metabolic Process Response To Corticosterone Dopamine Receptor Signaling Pathway Response To Organic Cyclic Compound Response To Glucocorticoid Response To Corticosteroid Response To Mineralocorticoid Response To Hormone Regulation Of Calcium Ion Transport Platelet Activation Regulation Of Cellular Localization Positive Regulation Of Corticotropin Secretion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Regulation Of Body Fluid Levels Regulation Of Corticotropin Secretion Signal Transduction Regulation Of Hormone Secretion Signaling Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Cell Communication Positive Regulation Of Peptide Secretion Response To Organic Substance Positive Regulation Of Calcium Ion Transport Response To Organonitrogen Compound Response To Lipid Positive Regulation Of Hormone Secretion Negative Regulation Of Transport Cellular Response To Stimulus Blood Coagulation Positive Regulation Of Calcium Ion Import Hemostasis Response To Steroid Hormone Cell Surface Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Calcium Ion Import Response To Immobilization Stress Behavior Wound Healing Activation Of Adenylate Cyclase Activity
Tagcloud ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary pomc proopiomelanocortin releasing steroid superfamily transformants transiently	allele alleles applicable asthmatics choice discriminate discriminating entered epidemiological era extensively feasible genotyping indian mutagenic north optimized perform pivotal primer primers restriction rflp rs1876828 snp throughput today undertook variant
Tagcloud (Difference) ?		acth adaptation adrenal antagonizes att axis corticotrope corticotropes corticotropin feedback gland glucocorticoid gre homolog hpa hypothalamic mediator nak ngre nur77 overcome pituitary pomc proopiomelanocortin releasing steroid superfamily transformants transiently	allele alleles applicable asthmatics choice discriminate discriminating entered epidemiological era extensively feasible genotyping indian mutagenic north optimized perform pivotal primer primers restriction rflp rs1876828 snp throughput today undertook variant
Tagcloud (Intersection) ?