CAPN15 and SOX4

Number of citations of the paper that reports this interaction (PubMedID 25969425)
0

Data Source:
BioGRID (two hybrid)

		CAPN15	SOX4
Description		calpain 15	SRY-box transcription factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis	Negative Regulation Of Transcription By RNA Polymerase II Pro-B Cell Differentiation Mitral Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Atrial Septum Primum Morphogenesis Noradrenergic Neuron Differentiation Regulation Of DNA-templated Transcription Nervous System Development Brain Development Heart Development Positive Regulation Of Cell Population Proliferation Gene Expression Glial Cell Proliferation Spinal Cord Development Glial Cell Development Neuron Differentiation T Cell Differentiation Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Somatic Stem Cell Population Maintenance Ascending Aorta Morphogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Camera-type Eye Morphogenesis Protein Stabilization Ventricular Septum Morphogenesis Mesenchyme Development Neuroepithelial Cell Differentiation Kidney Morphogenesis Hematopoietic Stem Cell Homeostasis Cellular Response To Glucose Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Degradation of the extracellular matrix	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494)	Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Bone mineral density ( 21533022) Cardiac hypertrophy ( 21348951) Endometrial cancer ( 27008869 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophilic esophagitis ( 34506852) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291)
Interacting Genes		7 interacting genes: CPEB2 DAZAP2 RNF216 RNF26 SOX4 TRAF2 UBC	34 interacting genes: AKT1 APOC3 AURKA CAPN15 CDKN2A CTR9 DACH1 EDF1 FOXH1 FZR1 IGF1 ITIH1 KRAS MINPP1 MNT MYC NANOGNB NF1 NF2 NSD3 PLD3 PLXNB1 RGSL1 RHOU RP1L1 SCNN1G SDCBP SMARCA4 STK11 TERT TNNI3 TSC1 UBE2I WT1
Entrez ID		6650	6659
HPRD ID		07220	01695
Ensembl ID		ENSG00000103326	ENSG00000124766
Uniprot IDs		O75808	Q06945
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitogen-activated Protein Kinase Kinase Kinase Binding Post-translational Protein Modification Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Defense Response To Virus Macromolecule Catabolic Process TORC2 Complex Disassembly Negative Regulation Of Cytoplasmic Translational Elongation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Modification-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Ascending Aorta Morphogenesis Pro-B Cell Differentiation Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Atrial Septum Primum Morphogenesis Regulation Of Gene Expression Protein Modification Process CD27 Signaling Pathway Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Translational Elongation Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Noradrenergic Neuron Differentiation Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Mitral Valve Morphogenesis Regulation Of Cytokine Production Protein Localization To Perinuclear Region Of Cytoplasm Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Activation Cellular Response To Oxygen-containing Compound Regulation Of Gamma-delta T Cell Differentiation Thioesterase Binding CD40 Receptor Complex CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway Catabolic Process Negative Regulation Of Cytoplasmic Translation Regulation Of Translational Elongation Lymphoid Progenitor Cell Differentiation Positive Regulation Of JUN Kinase Activity	Striated Muscle Cell Differentiation Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Regulation Of Cell Development Regulation Of Intracellular Signal Transduction Epithelial Cell Differentiation Muscle Cell Differentiation Regulation Of Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Signal Transduction Regulation Of Protein Localization To Nucleus Ras Protein Signal Transduction Positive Regulation Of Developmental Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Positive Regulation Of Catalytic Activity Cell Differentiation Regulation Of Developmental Process Intracellular Signaling Cassette Positive Regulation Of Cell Differentiation Developmental Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of MiRNA Transcription Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Cellular Developmental Process Regulation Of Cell Cycle Process Negative Regulation Of Developmental Process Regulation Of Catalytic Activity Regulation Of Cell Growth Regulation Of Multicellular Organismal Process Negative Regulation Of Transcription By RNA Polymerase II Forebrain Astrocyte Development Schwann Cell Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Intracellular Signal Transduction Myotube Differentiation Regulation Of MiRNA Transcription Rac Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Nervous System Development Regulation Of Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?