ATP1B2 and NGB

Number of citations: 0 (PubMedID 12958655)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		ATP1B2	NGB
Name		ATPase Na+/K+ transporting subunit beta 2	neuroglobin
Structure		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Plasma Membrane Sodium:potassium-exchanging ATPase Complex External Side Of Plasma Membrane Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Projection Membrane Cell Body Membrane Cell Periphery Astrocyte Projection Astrocyte End-foot Neuron To Neuron Synapse	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	ATPase Activator Activity Protein Binding Protein-macromolecule Adaptor Activity Protein Heterodimerization Activity ATPase Binding Transporter Activator Activity	GDP-dissociation Inhibitor Activity Oxygen Carrier Activity Protein Binding Oxidoreductase Activity Oxygen Binding Heme Binding Metal Ion Binding Nitrite Reductase Activity
	Biological Process	Retina Homeostasis Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Cell Adhesion Positive Regulation Of Neuron Projection Development Lateral Ventricle Development Third Ventricle Development Neuronal-glial Interaction Involved In Hindbrain Glial-mediated Radial Cell Migration Intracellular Potassium Ion Homeostasis Cell-substrate Adhesion Sodium Ion Export Across Plasma Membrane Photoreceptor Cell Maintenance Protein Stabilization Motor Behavior Membrane Repolarization Cell Communication By Electrical Coupling Involved In Cardiac Conduction Plasma Membrane Bounded Cell Projection Organization Transport Across Blood-brain Barrier Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Potassium Ion Import Across Plasma Membrane Negative Regulation Of Glial Cell Migration Potassium Ion Import Across Plasma Membrane	Response To Hypoxia Oxygen Transport Cellular Response To Hypoxia
Pathways		Basigin interactions Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Intracellular oxygen transport
Drugs		Bisacodyl Tegoprazan	None
GWAS		Brain morphology (MOSTest) ( 32665545 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Esophageal squamous cell carcinoma ( 25129146 ) Platelet count ( 32888494 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Sex hormone-binding globulin levels ( 22675492 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Type 2 diabetes (adjusted for BMI) ( 30297969 ) Waist circumference adjusted for body mass index ( 34021172 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: HLCS
Interacting Genes		2 interacting genes: CPEB2 NGB	23 interacting genes: AKT1 ATP1B2 BTBD2 C1orf94 DDIT4L FLOT1 GATAD2B GNAI1 GNAI2 GNAI3 GNAO1 IHO1 L3MBTL3 MAPK14 MEI4 NIF3L1 OTOS PTEN REL TDO2 TEPSIN VAC14 ZNF655
Entrez ID		482	58157
HPRD ID		01664	05602
Ensembl ID		ENSG00000129244	ENSG00000165553
Uniprot IDs		P14415	A0M8W9 Q9NPG2
PDB IDs		Not available	1OJ6 4MPM 7VQG 8GRZ 8WUB
GO Terms Enriched among Interactors		Cellular Response To Oxygen Levels Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cytoplasmic Translational Elongation Response To Decreased Oxygen Levels Response To Oxygen Levels Response To Hypoxia Nitrite Reductase Activity Negative Regulation Of Translational Elongation Negative Regulation Of Cytoplasmic Translation Regulation Of Translational Elongation GTPase Inhibitor Activity Oxygen Carrier Activity Ribosomal Large Subunit Binding GDP-dissociation Inhibitor Activity MRNA Regulatory Element Binding Translation Repressor Activity Oxygen Transport Translation Regulator Activity Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding Oxygen Binding MRNA 3'-UTR AU-rich Region Binding Regulation Of Cytoplasmic Translation Cellular Response To Stress Ribosome Binding Cellular Response To Insulin Stimulus Heme Binding MRNA 3'-UTR Binding	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Adenylate Cyclase Regulator Activity Meiotic DNA Double-strand Break Formation Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Receptor Binding Regulation Of Transport Myelin Maintenance Positive Regulation Of Myoblast Fusion Regulation Of Organ Growth Negative Regulation Of Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Myoblast Fusion G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Peptidyl-serine Phosphorylation Osteoblast Differentiation Response To Prostaglandin E Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Ciliary Basal Body Regulation Of Cholesterol Biosynthetic Process Centriolar Satellite Homologous Chromosome Pairing At Meiosis Positive Regulation Of Sodium Ion Transport GTPase Activity Positive Regulation Of D-glucose Import Regulation Of Smooth Muscle Cell Proliferation Regulation Of TRNA Methylation Positive Regulation Of Steroid Biosynthetic Process Lipopolysaccharide-mediated Signaling Pathway Neuronal-glial Interaction Involved In Hindbrain Glial-mediated Radial Cell Migration Negative Regulation Of Secretion By Cell Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Negative Regulation Of Synaptic Vesicle Clustering L-tryptophan Catabolic Process To Acetyl-CoA PAS Complex Coated Vesicle Membrane Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Insulin Secretion GTP Binding Positive Regulation Of Steroid Metabolic Process