GAA and NCF1

Number of citations of the paper that reports this interaction (PMID 16052631)
27

Data Source:
BioGRID (two hybrid)

		GAA	NCF1
Gene Name		glucosidase, alpha; acid	neutrophil cytosolic factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Lysosomal Membrane Membrane Extracellular Vesicular Exosome	Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	Alpha-1,4-glucosidase Activity Carbohydrate Binding Maltose Alpha-glucosidase Activity	Protein Binding Electron Carrier Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Maltose Metabolic Process Regulation Of The Force Of Heart Contraction Diaphragm Contraction Heart Morphogenesis Glycogen Catabolic Process Sucrose Metabolic Process Glucose Metabolic Process Lysosome Organization Locomotory Behavior Tissue Development Vacuolar Sequestering Muscle Cell Cellular Homeostasis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Cardiac Muscle Contraction	Response To Yeast Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Apoptotic Process Inflammatory Response Cellular Defense Response Cell Proliferation Superoxide Anion Generation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Respiratory Burst Negative Regulation Of Smooth Muscle Contraction Vascular Endothelial Growth Factor Receptor Signaling Pathway Hydrogen Peroxide Biosynthetic Process Interaction With Host Oxidation-reduction Process Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Phagosome Maturation
Pathways			Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs		Acarbose Miglitol
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EP300 HIVEP1 NCF1 NUMBL STAT2	23 interactors: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF4 NOXA1 PRKCA PRKCB PRKCD PRKCZ PRKDC SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		2548	653361
HPRD ID		06006
Ensembl ID		ENSG00000171298	ENSG00000158517
Uniprot IDs		P10253	P14598
PDB IDs			1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP
Enriched GO Terms of Interacting Partners?		Interaction With Symbiont Histone H2B Acetylation Innate Immune Response Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Neuroblast Division In Subventricular Zone Regulation Of Tubulin Deacetylation Respiratory Burst Involved In Defense Response Response To Yeast Cell Surface Receptor Signaling Pathway Immune Response Killing By Host Of Symbiont Cells Defense Response Hydrogen Peroxide Biosynthetic Process Positive Regulation By Host Of Viral Transcription N-terminal Protein Amino Acid Acetylation Respiratory Burst Forebrain Neuroblast Division Negative Regulation Of Smooth Muscle Contraction Cytokine-mediated Signaling Pathway Superoxide Anion Generation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Neutrophil Mediated Immunity Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Lateral Ventricle Development Viral Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Killing Of Cells Of Other Organism Somatic Stem Cell Division Cellular Response To Cytokine Stimulus N-terminal Protein Amino Acid Modification Defense Response To Fungus Regulation Of Cellular Response To Heat Immune System Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Leukocyte Mediated Cytotoxicity Hydrogen Peroxide Metabolic Process Leukotriene Metabolic Process Biosynthetic Process Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Transcription, DNA-templated Response To Cytokine Response To Fungus Response To Other Organism Regulation Of Type I Interferon-mediated Signaling Pathway	Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Histone H3-T6 Phosphorylation Platelet Activation Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Metabolic Process Peptidyl-threonine Phosphorylation Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Body Fluid Levels Immune Response Apoptotic Signaling Pathway Apoptotic Process Regulation Of Catalytic Activity Programmed Cell Death Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Phospholipase Activity Cell Death Regulation Of Protein Phosphorylation Death Blood Coagulation Regulation Of Cellular Protein Metabolic Process Hemostasis Cell Surface Receptor Signaling Pathway Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Organelle Organization Mitotic Cell Cycle Positive Regulation Of Lipase Activity Response To Interleukin-1 Innate Immune Response Regulation Of Glucose Transport Regulation Of Platelet Aggregation Regulation Of Protein Metabolic Process Muscle System Process Negative Regulation Of Glucose Transport Signaling Regulation Of Phosphorylation Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Protein Modification Process Protein Phosphorylation Peptidyl-serine Phosphorylation
Tagcloud ?		birds corrected correction deficient endocytic endocytosed endocytosis existed fibroblasts glucosidase glycogen hamster illustrate kd lasted lethal lysosomes maltase mammals man myoblasts nmol normalize normalized ovary pompe quail replacement subfractions	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Difference) ?		birds corrected correction deficient endocytic endocytosed endocytosis existed fibroblasts glucosidase glycogen hamster illustrate kd lasted lethal lysosomes maltase mammals man myoblasts nmol normalize normalized ovary pompe quail replacement subfractions	anticancer atlas ccle computational consequences cosmic driver encyclopedia harboring identifying illustrated investigating mapped midostaurin nucleic onto plek pocket precision projects researchers rwdd1 somatic tcga tended tipifarnib uncover vav3 vinorelbine
Tagcloud (Intersection) ?