GRK7 and PDE6D

Number of citations of the paper that reports this interaction (PubMedID 16473576)
0

Data Source:
HPRD (two hybrid, in vitro)

		GRK7	PDE6D
Description		G protein-coupled receptor kinase 7	phosphodiesterase 6D
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane Photoreceptor Disc Membrane	Cytoplasm Cytosol Cytoskeleton Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Rhodopsin Kinase Activity	GTPase Inhibitor Activity Protein Binding Small GTPase Binding
	Biological Process	Signal Transduction Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Opsin-mediated Signaling Pathway Protein Autophosphorylation	Visual Perception Sensory Perception Of Light Stimulus
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	ARL13B-mediated ciliary trafficking of INPP5E RAS processing
Drugs
Diseases
GWAS		Anti-herpes simplex virus 2 IgG seropositivity ( 33204752)	Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Interacting Genes		2 interacting genes: NEDD4 PDE6D	25 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS OTP PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR
Entrez ID		131890	5147
HPRD ID		07378	04056
Ensembl ID		ENSG00000114124	ENSG00000156973
Uniprot IDs		Q8WTQ7	B8ZZK5 O43924 Q6IB24
PDB IDs			1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW 7PAC 7PAD 7PAE 7Q9Q 7Q9R 7Q9S 7Q9U 7QF9 7QJK
Enriched GO Terms of Interacting Partners?		Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Channel Inhibitor Activity Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Formation Of Structure Involved In A Symbiotic Process Sodium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Potassium Channel Inhibitor Activity GTPase Inhibitor Activity Endocardial Cushion Development Negative Regulation Of Sodium Ion Transport Proline-rich Region Binding Receptor Catabolic Process RNA Polymerase Binding Negative Regulation Of Potassium Ion Transmembrane Transport Apicolateral Plasma Membrane Postsynaptic Cytosol Ionotropic Glutamate Receptor Binding Protein Targeting To Lysosome Viral Budding Negative Regulation Of Potassium Ion Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuromuscular Junction Development	GTPase Activity GTP Binding GDP Binding Nucleotide Binding Small GTPase-mediated Signal Transduction G Protein Activity Intracellular Signaling Cassette Ciliary Basal Body Intracellular Signal Transduction Mitotic Cytokinesis Midbody Rhodopsin Kinase Activity Regulation Of Cytoskeleton Organization Cytoskeleton-dependent Cytokinesis Centrosome Photoreceptor Connecting Cilium Hydrolase Activity Signal Transduction G Protein-coupled Receptor Kinase Activity Cellular Developmental Process Golgi Apparatus Extracellular Exosome Rap Protein Signal Transduction Regulation Of Opsin-mediated Signaling Pathway Protein Localization To Cilium Cell-cell Junction Organization Cytoskeleton Regulation Of Actin Cytoskeleton Organization Endothelial Tube Morphogenesis Regulation Of Actin Filament-based Process Regulation Of Modification Of Postsynaptic Structure Cellular Response To Forskolin Phagocytic Vesicle Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Response To Forskolin Trans-Golgi Network Transport Vesicle Protein Localization To Cell Periphery Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Modification Of Synaptic Structure Recycling Endosome Membrane Photoreceptor Disc Membrane Protein Kinase Binding Establishment Of Apical/basal Cell Polarity G-protein Beta/gamma-subunit Complex Binding Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Actin Filament Organization Cell Junction Assembly Establishment Or Maintenance Of Monopolar Cell Polarity
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