STX8 and CLN8

Number of citations of the paper that reports this interaction (PMID 23142642)
0

Data Source:
BioGRID (two hybrid)

		STX8	CLN8
Gene Name		syntaxin 8	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Integral Component Of Plasma Membrane SNARE Complex Late Endosome Membrane Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	SNAP Receptor Activity Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Transport Intracellular Protein Transport Vesicle Fusion Endosome To Lysosome Transport Early Endosome To Late Endosome Transport Regulation Of Protein Localization To Plasma Membrane	Age-dependent Response To Oxidative Stress Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Regulation Of Cell Size Lipid Biosynthetic Process Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Apoptotic Process Cellular Protein Catabolic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Negative Regulation Of Transferase Activity L-glutamate Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS			Gaucher disease severity ( 22388998)
Protein-Protein Interactions		17 interactors: ACVR1 CALM1 CLN8 COPA CREB3 NAPA NAPG NSF STX1A STX4 STX7 TGFBR1 UBC VPS11 VPS18 VTI1B WDR91	29 interactors: ARL6IP5 BNIP3 BNIP3L C14orf1 CD9 CYB5B GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUFSP
Entrez ID		9482	2055
HPRD ID		05012	06383
Ensembl ID			ENSG00000182372
Uniprot IDs		Q9UNK0	Q9UBY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Organization Membrane Fusion Vesicle Docking Membrane Docking Intracellular Protein Transport Cellular Localization Cellular Protein Localization Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Cellular Localization Golgi Vesicle Transport Vesicle Fusion Intra-Golgi Vesicle-mediated Transport Exocytosis Secretion Organelle Fusion Vesicle Organization Post-Golgi Vesicle-mediated Transport Transport Secretion By Cell Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Priming Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization Vesicle Docking Involved In Exocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Pathway-restricted SMAD Protein Phosphorylation Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Pharyngeal System Development Positive Regulation Of Transport Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neurotransmitter Levels Organelle Localization Activin Receptor Signaling Pathway Neurotransmitter Transport Regulation Of Synaptic Vesicle Exocytosis Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Apoptotic Process Cell-cell Signaling Negative Regulation Of Apoptotic Process Response To Transforming Growth Factor Beta	Mitochondrial Protein Catabolic Process Transport Membrane Organization Apoptotic Signaling Pathway Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Establishment Of Localization In Cell Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Membrane Fusion Apoptotic Process Cellular Localization Programmed Cell Death Cell Death Death Mitochondrial Transport Organelle Organization Intracellular Transport Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Oligodendrocyte Development Substantia Nigra Development Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Neural Nucleus Development Gliogenesis Mitochondrial Membrane Organization Protein Transport Dense Core Granule Maturation Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Process Oligodendrocyte Differentiation Establishment Of Protein Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Stress Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Serotonin Uptake Midbrain Development Glial Cell Development Cellular Response To Hypoxia Cell Communication Cellular Response To Decreased Oxygen Levels Negative Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway
Tagcloud ?		cd3 ctls eliminate exocytosis granules granzymes groundwork laying lgs lytic nsf perforin snap snare snares stx13 stx16 stx3 stx4 stx6 stx7 synapse synapses syntaxin1b2 tumorigenic vamp3 vamp4 vesicle vti1b	brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Difference) ?		cd3 ctls eliminate exocytosis granules granzymes groundwork laying lgs lytic nsf perforin snap snare snares stx13 stx16 stx3 stx4 stx6 stx7 synapse synapses syntaxin1b2 tumorigenic vamp3 vamp4 vesicle vti1b	brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Intersection) ?