SCYL1

Description		SCY1 like pseudokinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Centrosome Cytosol Cytoskeleton Membrane COPI Vesicle Coat
	Molecular Function	DNA Binding Protein Kinase Activity Protein Binding ATP Binding Cadherin Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Inflammatory Response Intracellular Protein Localization Vesicle-mediated Transport Spinal Cord Motor Neuron Differentiation Neuron Development
Pathways
Drugs		Grn163l
Diseases
GWAS		Acne (severe) ( 24927181) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femoral neck bone mineral density ( 22504420) Hip index ( 34021172) Refractive error ( 32231278) Vertical cup-disc ratio ( 20548946)
Interacting Genes		21 interacting genes: APP ARF1 ARF3 AXIN1 CCNF CD93 CDC25A CHD1L COIL COPA COPE DAPK1 DDX6 GORAB LENG1 NOD2 PIN1 PLEKHF2 SMURF1 SNCA TCEA2
Entrez ID		57410
HPRD ID		06414
Ensembl ID		ENSG00000142186
Uniprot IDs		E9PK59 E9PPN3 Q96KG9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Intracellular Transport Regulation Of Protein Metabolic Process Vesicle-mediated Transport Establishment Of Localization In Cell Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Macrophage Activation Protein Localization To Axon Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Protein Domain Specific Binding COPI-coated Vesicle Membrane COPI-coated Vesicle COPI Vesicle Coat I-SMAD Binding Positive Regulation Of JNK Cascade Cellular Localization Regulation Of Neurotransmitter Uptake Copper Ion Homeostasis Transport Vesicle Protein Serine/threonine Kinase Binding Cellular Response To Copper Ion Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cytoplasmic Vesicle R-SMAD Binding Myeloid Leukocyte Activation Amyloid Fibril Formation Establishment Of Protein Localization Growth Cone Microglial Cell Activation Negative Regulation Of Protein Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion Regulation Of JNK Cascade Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Leukocyte Activation Involved In Inflammatory Response Golgi Apparatus Mitotic Cleavage Furrow Ingression Intra-Golgi Vesicle-mediated Transport DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Concave Side Of Sperm Head Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cis-trans Isomerase Activity
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