M1AP and DES

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		M1AP	DES
Description		meiosis 1 associated protein	desmin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Nucleus Nuclear Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Fascia Adherens Intercalated Disc Membrane Z Disc Neuromuscular Junction Sarcolemma Contractile Muscle Fiber Intermediate Filament Cytoskeleton Cell Tip Extracellular Exosome Cardiac Myofibril Supramolecular Fiber
	Molecular Function	Protein Binding Identical Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Chromatin Organization RNA Processing Meiosis I Spermatogenesis Female Gamete Generation Cell Differentiation Male Meiosis Chromosome Separation	Muscle Contraction Nuclear Envelope Organization Cytoskeleton Organization Regulation Of Heart Contraction Intermediate Filament Organization Skeletal Muscle Organ Development
Pathways			Striated Muscle Contraction
Drugs
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Dilated cardiomyopathy (DCM) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Scapuloperoneal myopathy (SPM)
GWAS		Refractive error ( 32231278)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624)
Interacting Genes		14 interacting genes: BAHD1 CRX CWF19L2 DES GOLGA6L9 LMNB1 OTX1 OTX2 PLEKHA2 POLR3GL SIAH1 TRIP13 UBL3 ZNF740	58 interacting genes: AURKB BAG5 BRCA1 C1orf216 CAPN1 CDC73 CLIP4 CRYAB CT55 CWF19L2 DDX6 DSP DUX1 DUX4 EHHADH ENO1 GOLGA6L9 HSPB1 ITSN1 KRT13 KRT15 KRT20 KRT33B KRT37 LBX1 LENG1 LMO4 LONRF3 M1AP MAPKAPK2 NEB NEFL NEK6 PIAS2 PIH1D2 PKD1 PLEKHA5 POLR2G PPL PPP1R18 PRPH RNF4 ROCK1 S100A1 S100B SHBG SNAPIN SPTAN1 SYNC SYNM TCEA2 TFIP11 TRIM55 TRIM63 TRIM7 UBE2I YES1 ZMYM5
Entrez ID		130951	1674
HPRD ID		14047	00514
Ensembl ID		ENSG00000159374	ENSG00000175084
Uniprot IDs		B3KX03 Q8TC57	P17661 Q53SB5
PDB IDs
Enriched GO Terms of Interacting Partners?		Sequence-specific Double-stranded DNA Binding Nuclear Envelope Organization Midbrain Development	Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Structural Molecule Activity Contractile Muscle Fiber Cytoskeleton Organization M Band Cytoskeleton Structural Constituent Of Skin Epidermis Protein Binding Z Disc Supramolecular Fiber Organization Keratin Filament Cytoplasm Intermediate Filament Cytoskeleton Cornified Envelope Tissue Morphogenesis Organelle Organization Morphogenesis Of An Epithelium Extracellular Exosome Anterograde Axonal Transport
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