NEU4 and RHOXF2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		NEU4	RHOXF2
Gene Name		sialidase 4	Rhox homeobox family, member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Lysosome Organelle Inner Membrane Lysosomal Lumen	Nucleus
	Molecular Function	Exo-alpha-sialidase Activity Protein Binding Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity	Protein Binding Sequence-specific DNA Binding
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Glycoprotein Catabolic Process Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process	Regulation Of Transcription, DNA-templated
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: AP2B1 MDFI PLSCR1 PSMA3 RBPMS RHOXF2 TCF4 TRIP6	56 interactors: AES ARID5A ATN1 ATXN1 CCDC33 CCNK CHAC1 CLASRP CLDN7 CRYBA1 DAB1 DAZAP2 DEDD2 DTX2 DVL2 EFEMP2 EWSR1 FAM103A1 FAM46B FAM46C FAM46D FBF1 HNRNPLL HOXC13 KRTAP19-5 KRTAP19-7 LASP1 LENG8 LSM4 LZTS2 MAGED1 MED7 MVP NANOG NEU4 PITX1 PLOD3 POLR3D POU2AF1 PSMF1 RADIL RBFOX1 RBFOX2 RBM11 RBPMS SERF2 SNAPC1 SUMO1 TMCC2 TOLLIP TRIP13 UPF1 UTP6 VAC14 VPS25 ZBTB32
Entrez ID		129807	84528
HPRD ID		12249	02345
Ensembl ID		ENSG00000204099	ENSG00000131721
Uniprot IDs		B3KR54 Q8WWR8	Q9BQY4
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Transport Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Transport Regulation Of Protein Localization Regulation Of Wnt Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Transport Regulation Of Cellular Localization Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cellular Metabolic Process Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Negative Regulation Of Canonical Wnt Signaling Pathway Maintenance Of DNA Repeat Elements Regulation Of Gene Expression Positive Regulation Of Transport Release Of Cytoplasmic Sequestered NF-kappaB Regulation Of Metabolic Process Phosphatidylserine Biosynthetic Process Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Hindgut Morphogenesis Positive Regulation Of Intracellular Signal Transduction Embryonic Genitalia Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Gene Expression Myoblast Fate Commitment Antigen Processing And Presentation Of Peptide Antigen	RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression MRNA Metabolic Process Cellular Metabolic Process MRNA Processing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Radial Glia Guided Migration Of Purkinje Cell Anatomical Structure Development Regulation Of RNA Splicing Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Developmental Process Regulation Of Cellular Process Negative Regulation Of Gene Expression Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process RNA Splicing Negative Regulation Of Wnt Signaling Pathway Cellular Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Cell Migration In Hindbrain Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Signaling Positive Regulation Of Protein Modification Process
Tagcloud ?		1140f01 9i acetylneuraminic alliance antipsychotic bim dana deoxy didehydro galardin gm6001 gpcr htc htcs irbeta irs1 neu1 neu3 neuraminidase neuromedin olanzapine oseltamivir overly piperazine sialidase sialidosis tamiflu uncover wg544	ba carcinogenesis cdna cloning expresses f3 focused gadd45b gastric glioma hf6 hgc27 homeobox irradiated libraries lines oncogenes pim quickly render rendered repressor reproductive retrovirus searched sublethally transduced transplanted
Tagcloud (Difference) ?		1140f01 9i acetylneuraminic alliance antipsychotic bim dana deoxy didehydro galardin gm6001 gpcr htc htcs irbeta irs1 neu1 neu3 neuraminidase neuromedin olanzapine oseltamivir overly piperazine sialidase sialidosis tamiflu uncover wg544	ba carcinogenesis cdna cloning expresses f3 focused gadd45b gastric glioma hf6 hgc27 homeobox irradiated libraries lines oncogenes pim quickly render rendered repressor reproductive retrovirus searched sublethally transduced transplanted
Tagcloud (Intersection) ?