NEU4

Gene Name		sialidase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Lysosome Organelle Inner Membrane Lysosomal Lumen
	Molecular Function	Exo-alpha-sialidase Activity Protein Binding Exo-alpha-(2->3)-sialidase Activity Exo-alpha-(2->6)-sialidase Activity Exo-alpha-(2->8)-sialidase Activity
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Glycoprotein Catabolic Process Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Oligosaccharide Catabolic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions		8 interactors: AP2B1 MDFI PLSCR1 PSMA3 RBPMS RHOXF2 TCF4 TRIP6
Entrez ID		129807
HPRD ID		12249
Ensembl ID		ENSG00000204099
Uniprot IDs		B3KR54 Q8WWR8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Transport Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Transport Regulation Of Protein Localization Regulation Of Wnt Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Transport Regulation Of Cellular Localization Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cellular Metabolic Process Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Negative Regulation Of Canonical Wnt Signaling Pathway Maintenance Of DNA Repeat Elements Regulation Of Gene Expression Positive Regulation Of Transport Release Of Cytoplasmic Sequestered NF-kappaB Regulation Of Metabolic Process Phosphatidylserine Biosynthetic Process Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Hindgut Morphogenesis Positive Regulation Of Intracellular Signal Transduction Embryonic Genitalia Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Gene Expression Myoblast Fate Commitment Antigen Processing And Presentation Of Peptide Antigen
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