COL8A2 and TFAM

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		COL8A2	TFAM
Name		collagen type VIII alpha 2 chain	transcription factor A, mitochondrial
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type VIII Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Protein-containing Complex Mitochondrial Nucleoid
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity	Mitochondrial Promoter Sequence-specific DNA Binding Transcription Coactivator Binding DNA Binding Chromatin Binding RNA Binding Protein Binding Heat Shock Protein Binding Mitochondrial Transcription Factor Activity Sequence-specific DNA Binding
	Biological Process	Angiogenesis Endothelial Cell Proliferation Cell Adhesion Extracellular Matrix Organization Camera-type Eye Morphogenesis Cell-cell Adhesion	Response To Hypoxia Mitochondrial Transcription Transcription Initiation At Mitochondrial Promoter Response To Nutrient Mitochondrial Respiratory Chain Complex Assembly
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization	Mitochondrial transcription initiation Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation
Diseases		Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy Posterior polymorphous corneal dystrophy (PPCD)	None
GWAS		Central corneal thickness ( 29760442 32528159 ) Corneal structure ( 23291589 ) Early spontaneous preterm birth ( 31194736 ) Intraocular pressure ( 29617998 29785010 31959993 )	Blood urea nitrogen levels ( 29403010 ) Height ( 23456168 ) Metabolite levels ( 23823483 ) Midgestational circulating levels of PCBs ( 28235828 ) Mitochondrial heteroplasmy measurement ( 33731350 ) Refractive error ( 32231278 )
Interacting Genes		18 interacting genes: ARL13B ATP6V0E1 BSND COL8A1 CREB3L1 CYB5R3 DARS2 FAM209A FNDC9 GPR152 GPX8 LMNA MUC1 PEX12 PLEKHO1 SGTA TFAM TMX2	10 interacting genes: AGTRAP ARL6IP1 COL8A2 MGST3 PNP STATH TECR TFB1M TFB2M TSPAN1
Entrez ID		1296	7019
HPRD ID		08347	02702
Ensembl ID		ENSG00000171812	ENSG00000108064
Uniprot IDs		E9PP49 P25067	E5KSU5 Q00059
PDB IDs		Not available	3FGH 3TMM 3TQ6 4NNU 4NOD 6ERP 6ERQ 6HB4 6HC3 7LBW 7LBX
GO Terms Enriched among Interactors		None	RRNA (adenine-N6,N6-)-dimethyltransferase Activity Mitochondrial Transcription Factor Activity Transcription Initiation At Mitochondrial Promoter RRNA Methylation RRNA Modification Mitochondrial RNA Metabolic Process Mitochondrial Nucleoid Collagen Type VIII Trimer Purine-nucleoside Phosphorylase Activity Purine Nucleobase Binding Urate Biosynthetic Process Nicotinamide Riboside Catabolic Process Nucleobase-containing Compound Biosynthetic Process Guanosine Phosphorylase Activity Inosine Catabolic Process Deoxyinosine Catabolic Process Extracellular Matrix Constituent, Lubricant Activity Very-long-chain Enoyl-CoA Reductase Activity DNA-templated Transcription Initiation RNA Methylation Small Molecule Biosynthetic Process Endoplasmic Reticulum Membrane Nucleoside Binding DAMP Catabolic Process Deoxyadenosine Catabolic Process Structural Constituent Of Tooth Enamel Hydroxyapatite Binding Very-long-chain Fatty Acyl-CoA Dehydrogenase Activity Positive Regulation Of L-glutamate Import Across Plasma Membrane Macromolecule Methylation Angiotensin Type II Receptor Activity RRNA (adenine-N6-)-methyltransferase Activity Leukotriene-C4 Synthase Activity Purine Ribonucleoside Catabolic Process Purine Deoxyribonucleoside Metabolic Process IMP Catabolic Process Regulation Of Endoplasmic Reticulum Tubular Network Organization Deoxyribonucleoside Catabolic Process Pentosyltransferase Activity Saliva Secretion Sec61 Translocon Complex Endoplasmic Reticulum Tubular Network Formation RNA Modification Purine Ribonucleoside Salvage Purine Nucleoside Catabolic Process Methyltransferase Activity Allantoin Metabolic Process Endoplasmic Reticulum Tubular Network Membrane Organization Mitochondrial Transcription Urate Metabolic Process