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CST9L and CCR5
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
CST9L
CCR5
Gene Name
cystatin 9-like
chemokine (C-C motif) receptor 5 (gene/pseudogene)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Cytoplasm
Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Molecular Function
Cysteine-type Endopeptidase Inhibitor Activity
Actin Binding
Phosphatidylinositol Phospholipase C Activity
Chemokine Receptor Activity
Protein Binding
Coreceptor Activity
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Chemokine (C-C Motif) Ligand 5 Binding
Biological Process
Negative Regulation Of Endopeptidase Activity
MAPK Cascade
Dendritic Cell Chemotaxis
Calcium Ion Transport
Chemotaxis
Inflammatory Response
Immune Response
Cellular Defense Response
Cell Surface Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Viral Process
Calcium-mediated Signaling
Signaling
Entry Into Host Cell
Chemokine-mediated Signaling Pathway
Response To Cholesterol
Cellular Response To Lipopolysaccharide
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
HIV Infection
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Metabolic disorders of biological oxidation enzymes
Early Phase of HIV Life Cycle
GPCR downstream signaling
HIV Life Cycle
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events
Binding and entry of HIV virion
Drugs
Maraviroc
Diseases
GWAS
Cystatin C (
17903292
)
Celiac disease (
20190752
)
Protein-Protein Interactions
6 interactors:
CCR5
KRTAP10-3
KRTAP10-9
NOTCH2NL
SLC22A2
TAB2
41 interactors:
ADRBK1
ADRBK2
AFP
ARL6IP5
ARRB1
CCL11
CCL13
CCL14
CCL16
CCL2
CCL3
CCL3L1
CCL3L3
CCL4
CCL5
CCL7
CCL8
CD4
CST9L
CTBP2
CXCR4
DNM2
ETV5
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
IL24
JAK1
JAK2
LCK
ORM1
PRAF2
PSMA5
PTK2
PTK2B
STAT1
STAT3
STAT5A
TXK
Entrez ID
128821
1234
HPRD ID
16769
03223
Ensembl ID
ENSG00000101435
ENSG00000160791
Uniprot IDs
Q9H4G1
A0A502
P51681
Q38L21
PDB IDs
1ND8
1NE0
1OPN
1OPT
1OPW
2L87
2RLL
2RRS
4MBS
Enriched GO Terms of Interacting Partners
?
MAPK Cascade
Signal Transduction By Phosphorylation
Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Choline Transport
Sarcoplasmic Reticulum Calcium Ion Transport
Dendritic Cell Chemotaxis
Neurotransmitter Biosynthetic Process
Histamine Transport
Quaternary Ammonium Group Transport
Signaling
Cell Communication
Response To Cholesterol
Dendritic Cell Migration
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Neurotransmitter Metabolic Process
Drug Transmembrane Transport
Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Sequestering Of Calcium Ion
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Ammonium Transmembrane Transport
Organic Cation Transport
Drug Transport
Entry Into Host Cell
Calcium Ion Transport Into Cytosol
Cytosolic Calcium Ion Transport
Cell Surface Receptor Signaling Pathway
Cell-cell Signaling
Toll-like Receptor 5 Signaling Pathway
Cellular Defense Response
Toll-like Receptor 10 Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Chemokine-mediated Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Response To Stress
Cell Chemotaxis
Defense Response
Immune Response
Immune System Process
Cellular Response To Stimulus
Inflammatory Response
Cell Migration
Cell Motility
Response To Stimulus
Response To External Stimulus
Signaling
Locomotion
Cell Communication
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Positive Regulation Of Catalytic Activity
Regulation Of Catalytic Activity
Signal Transduction
Regulation Of Cell Proliferation
Chemotaxis
Movement Of Cell Or Subcellular Component
Positive Regulation Of Metabolic Process
Eosinophil Chemotaxis
Eosinophil Migration
Cellular Metal Ion Homeostasis
Cell Activation
Cellular Cation Homeostasis
Positive Regulation Of Signal Transduction
Regulation Of Lymphocyte Migration
Cellular Ion Homeostasis
Metal Ion Homeostasis
Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Natural Killer Cell Chemotaxis
Cellular Chemical Homeostasis
Regulation Of Signal Transduction
Regulation Of Signaling
Chemical Homeostasis
Response To Cytokine
Ion Homeostasis
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cell Migration
Regulation Of Cell Motility
Positive Regulation Of Intracellular Signal Transduction
Growth Hormone Receptor Signaling Pathway
Leukocyte Chemotaxis
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Granulocyte Chemotaxis
Cellular Response To Growth Hormone Stimulus
Tagcloud
?
7b11
aminoxypentane
augmented
broadening
ccr1
ccr2
ccr3
chemokine
chemokines
chemotactic
cxc
cxcr1
eotaxin
hcc2
leukocytes
mcp
migrate
migrated
mip
monocyte
orienting
pmn
polymorphonuclear
prototypic
rantes
reorients
speculate
th1
th2
Tagcloud (Difference)
?
7b11
aminoxypentane
augmented
broadening
ccr1
ccr2
ccr3
chemokine
chemokines
chemotactic
cxc
cxcr1
eotaxin
hcc2
leukocytes
mcp
migrate
migrated
mip
monocyte
orienting
pmn
polymorphonuclear
prototypic
rantes
reorients
speculate
th1
th2
Tagcloud (Intersection)
?