CST9L and TAB2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CST9L	TAB2
Name		cystatin 9 like	TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Plasma Membrane Endosome Membrane Membrane
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Molecular Adaptor Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Antimicrobial Humoral Response	Inflammatory Response Canonical NF-kappaB Signal Transduction Heart Development Response To Bacterium Negative Regulation Of Autophagy Response To Lipopolysaccharide Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Kinase Activity Protein K63-linked Ubiquitination
Pathways		None	Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
GWAS		Cystatin C levels ( 17903292 )	Breast cancer ( 22383897 29059683 ) Coronary artery disease ( 33020668 ) Diverticulitis ( 28585551 ) Dupuytren's disease ( 21732829 28886342 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 )
Interacting Genes		10 interacting genes: CCR5 CYSRT1 KRTAP10-3 KRTAP10-9 KRTAP5-1 MEI4 NBPF19 NOTCH2NLA SLC22A2 TAB2	44 interacting genes: APP CAMK2A CST9L EIF2AK2 EMILIN1 ERBB4 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 HSF2BP IKBKB IKBKG IRAK1 KRT85 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPIL3 PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TPM3 TRAF2 TRAF3IP1 TRAF6 TRIM45 TTN UBC UBE2I VIM VPS52 XIAP YWHAZ ZBTB16 ZFP64 ZNF143
Entrez ID		128821	23118
HPRD ID		16769	05483
Ensembl ID		ENSG00000101435	ENSG00000055208
Uniprot IDs		A0A140VJH1 Q9H4G1	B4DIR9 Q9NYJ8
PDB IDs		Not available	2DAE 2WWZ 2WX0 2WX1 9AVT 9AVW
GO Terms Enriched among Interactors		Intermediate Filament	Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of JNK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Metabolic Process Defense Response Regulation Of Signaling Positive Regulation Of Defense Response Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Communication Identical Protein Binding Regulation Of Macromolecule Metabolic Process Protein Modification Process Positive Regulation Of Multicellular Organismal Process MyD88-dependent Toll-like Receptor Signaling Pathway Histone Deacetylase Complex Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-activating Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Innate Immune Response-activating Signaling Pathway Response To Other Organism