COL4A5 and OSM

Number of citations of the paper that reports this interaction (PubMedID 11711546)
0

Data Source:
HPRD (in vitro)

		COL4A5	OSM
Description		collagen type IV alpha 5 chain	oncostatin M
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction	Extracellular Region Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Signaling Receptor Binding Cytokine Activity Oncostatin-M Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Neuromuscular Junction Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway	Positive Regulation Of Acute Inflammatory Response Immune Response Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Interleukin-17 Production Positive Regulation Of Peptidyl-serine Phosphorylation Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Regulation of expression of SLITs and ROBOs Attachment of bacteria to epithelial cells	Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions
Drugs
Diseases		Alport syndrome
GWAS			Coronary artery disease ( 29212778 33020668) Delirium ( 29631748) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233) Myocardial infarction ( 33532862) Nephropathy ( 21399633) Suicidal ideation ( 30145303) Tonsillectomy ( 27941131)
Interacting Genes		46 interacting genes: ABHD4 ANTXR2 ANXA7 APP ATP6V0B BSND CD53 CD79A CD93 CDKN1A CERS4 CLDN7 DAZAP2 DCN ELOVL4 ERGIC3 FAM209A FBLN2 FFAR2 FN1 GPX8 HABP2 KCNJ6 MATN2 MFF MMP9 MTIF3 NCR3LG1 NEMP1 NR1H2 OSM RELL2 RNF10 SAR1A SERPINE2 SLC10A4 SLC10A6 SLC16A2 SLC18A1 SLC35H1 SLC39A2 SMN1 THAP4 TK1 TMEM80 TSPO2	13 interacting genes: APP COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 IL6ST LIFR OSMR S100P TNNT1 ZNF410
Entrez ID		1287	5008
HPRD ID		02363	01300
Ensembl ID		ENSG00000188153	ENSG00000099985
Uniprot IDs		A7MBN3 P29400 Q49AM6	B5MCX1 P13725
PDB IDs		5NAZ 6WKU	1EVS 8V29 8V2A
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Protein Serine/threonine Kinase Binding Glycosaminoglycan Binding Bile Acid:sodium Symporter Activity	Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Extracellular Matrix Structural Constituent Oncostatin-M Receptor Activity Endoplasmic Reticulum Lumen Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Extracellular Matrix Organization Extracellular Structure Organization Enzyme-linked Receptor Protein Signaling Pathway Extracellular Region Extracellular Matrix Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Complex Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Cell Surface Receptor Signaling Pathway Cytokine Binding Growth Factor Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Cytokine Receptor Activity Receptor Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Glomerular Basement Membrane Development Cell Body Transition Metal Ion Binding External Side Of Plasma Membrane Positive Regulation Of Acute Inflammatory Response Integrin Binding Positive Regulation Of Inflammatory Response Signal Transduction Cell Junction Organization Neuromuscular Junction Development Regulation Of Acute Inflammatory Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Cytokine Slow-twitch Skeletal Muscle Fiber Contraction Response To Peptide Synapse Organization Regulation Of Cell Population Proliferation Acetylcholine Receptor Activator Activity Lipoprotein Particle
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