LUM and ACAN

Number of citations: 0 (PubMedID 15505028)
Data Source: HPRD (in vitro)

		LUM	ACAN
Name		lumican	aggrecan
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrillar Collagen Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding
	Biological Process	Visual Perception Collagen Fibril Organization Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Response To Growth Factor Response To Aroclor 1254	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development
Pathways		Keratan sulfate biosynthesis Keratan sulfate degradation Integrin cell surface interactions ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		Copper	Ilomastat
Diseases		None	Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis Spondyloepiphyseal dysplasia, Kimberley type
GWAS		Blood protein levels ( 30072576 ) Intraocular pressure ( 29617998 ) Metabolite levels ( 23823483 ) Pulmonary function (smoking interaction) ( 23284291 ) Systolic blood pressure (alcohol consumption interaction) ( 24376456 )	Age-related hearing impairment ( 27764096 ) Appendicular lean mass ( 33097823 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body size at age 10 ( 32376654 ) Dupuytren's disease ( 28886342 ) Height ( 20881960 31562340 28552196 33713608 18391952 28270201 25429064 25282103 25133637 23563607 21998595 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Infant length ( 25281659 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 )
Novel Interactors		None recorded	5 novel interactors: BLM IDH2 MAN2A2 SLCO3A1 STARD5
Interacting Genes		6 interacting genes: ACAN CFTR COL1A2 GNAQ MMP14 TRA2B	18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR
Entrez ID		4060	176
HPRD ID		02793	01123
Ensembl ID		ENSG00000139329	ENSG00000157766
Uniprot IDs		A0A384N669 P51884	A0A5K1VW97 P16112
PDB IDs		Not available	4MD4 7RDV
GO Terms Enriched among Interactors		Skeletal System Development Response To Ketone Extracellular Matrix Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Collagen Metabolic Process Protein Heterotrimerization Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Golgi Lumen Extracellular Matrix Structural Constituent Odontogenesis Animal Organ Morphogenesis Positive Regulation Of Anion Channel Activity Collagen Type I Trimer Positive Regulation Of Monoatomic Anion Transport Response To Odorant Positive Regulation Of Enamel Mineralization Response To Genistein Transepithelial Water Transport Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway GDF15-GFRAL Signaling Pathway Response To Hydroxyisoflavone Macropinosome Positive Regulation Of Tooth Mineralization Astrocyte Cell Migration Cerebral Cortex Regionalization Chloride Channel Inhibitor Activity Cellular Response To Oxygen-containing Compound Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Phenylpropanoid Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Phospholipase C-activating Serotonin Receptor Signaling Pathway Amelogenesis Extracellular Structure Organization Fibrillar Collagen Trimer Extracellular Matrix Organization Response To Alcohol Perineuronal Net ATPase-coupled Inorganic Anion Transmembrane Transporter Activity System Development Regulation Of Body Fluid Levels Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Monoatomic Anion Transport	Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Metalloendopeptidase Activity Collagen Catabolic Process Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Peptidase Activity Hydrolase Activity Extracellular Region Extracellular Space Serine-type Endopeptidase Activity Proteolysis Cellular Response To UV-A Ovulation From Ovarian Follicle Ovulation Cycle Process Response To UV-A Ovulation Protein Metabolic Process Fibronectin Binding Zinc Ion Binding Endodermal Cell Differentiation Regulation Of Cell Migration Ovarian Follicle Development Regulation Of Cell Motility Metal Ion Binding Macromolecule Metabolic Process Regulation Of Locomotion Cellular Response To Radiation Perineuronal Net Extracellular Matrix Structural Constituent Conferring Compression Resistance Cellular Response To UV Rhythmic Process Cellular Response To Light Stimulus Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Neuron Projection Regeneration Regulation Of Axon Regeneration Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Neuron Projection Regeneration Extracellular Matrix Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion