LUM

Description		lumican
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrillar Collagen Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance
	Biological Process	Visual Perception Collagen Fibril Organization Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Response To Growth Factor Response To Aroclor 1254
Pathways		Keratan sulfate biosynthesis Keratan sulfate degradation Integrin cell surface interactions ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Pulmonary function (smoking interaction) ( 23284291) Systolic blood pressure (alcohol consumption interaction) ( 24376456)
Interacting Genes		6 interacting genes: ACAN CFTR COL1A2 GNAQ MMP14 TRA2B
Entrez ID		4060
HPRD ID		02793
Ensembl ID		ENSG00000139329
Uniprot IDs		A0A384N669 P51884
PDB IDs
Enriched GO Terms of Interacting Partners?		Skeletal System Development Response To Ketone Extracellular Matrix Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Collagen Metabolic Process Protein Heterotrimerization Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway Golgi Lumen Extracellular Matrix Structural Constituent Odontogenesis Animal Organ Morphogenesis Positive Regulation Of Anion Channel Activity Collagen Type I Trimer Positive Regulation Of Monoatomic Anion Transport Response To Odorant Positive Regulation Of Enamel Mineralization Response To Genistein Transepithelial Water Transport Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway GDF15-GFRAL Signaling Pathway Response To Hydroxyisoflavone Macropinosome Positive Regulation Of Tooth Mineralization Astrocyte Cell Migration Cerebral Cortex Regionalization Chloride Channel Inhibitor Activity Cellular Response To Oxygen-containing Compound Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Phenylpropanoid Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Phospholipase C-activating Serotonin Receptor Signaling Pathway Amelogenesis Extracellular Structure Organization Fibrillar Collagen Trimer Extracellular Matrix Organization Response To Alcohol Perineuronal Net ATPase-coupled Inorganic Anion Transmembrane Transporter Activity System Development Regulation Of Body Fluid Levels Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Regulation Of Monoatomic Anion Transport
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