LSM12 and LSM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LSM12	LSM3
Description		LSM12 homolog	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process		MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing P-body Assembly
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Chronotype ( 30696823) Dilated cardiomyopathy ( 33677556) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		5 interacting genes: CEBPA GOLM1 LSM2 LSM3 NTAQ1	45 interacting genes: CCND3 CDKN2D CEP95 CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EIF4G3 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN THOC5 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		124801	27258
HPRD ID		08701	06283
Ensembl ID		ENSG00000161654	ENSG00000170860
Uniprot IDs		K7ELG9 Q3MHD2	P62310
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Lsm1-7-Pat1 Complex Lsm2-8 Complex U6 SnRNP Precatalytic Spliceosome U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding P-body Catalytic Step 2 Spliceosome Protein-N-terminal Glutamine Amidohydrolase Activity Response To Vitamin B2 C/EBP Complex U6 SnRNA 3'-end Binding Protein-N-terminal Asparagine Amidohydrolase Activity CHOP-C/EBP Complex White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions Response To Phenylpropanoid Fat Cell Proliferation Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding RNA Metabolic Process Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway STAT Family Protein Binding Osteoblast Development Ribonucleoprotein Complex P-body Assembly RNA Splicing Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides U6 SnRNA Binding Spliceosomal Tri-snRNP Complex Assembly MRNA Processing Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Epithelial Cell Maturation	RNA Splicing MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing U4/U6 X U5 Tri-snRNP Complex RNA Binding MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex RNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process U7 SnRNP Lsm2-8 Complex Precatalytic Spliceosome U6 SnRNP Spliceosomal SnRNP Assembly Catalytic Step 2 Spliceosome Nucleoplasm Methylosome Ribonucleoprotein Complex Lsm1-7-Pat1 Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus MRNA Catabolic Process RNA Catabolic Process Spliceosomal Complex Assembly 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U4 SnRNP Protein-RNA Complex Assembly Cytoplasm Macromolecule Metabolic Process U1 SnRNP U5 SnRNP Nucleobase-containing Compound Catabolic Process PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex U2-type Catalytic Step 2 Spliceosome U6 SnRNA Binding P-body RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process Cytosol U7 SnRNA Binding
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