LSM12 and LSM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LSM12	LSM2
Description		LSM12 homolog	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytoplasm Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding	RNA Binding Protein Binding U6 SnRNA Binding Small GTPase Binding
	Biological Process		Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing MRNA Catabolic Process RNA Splicing
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Rosacea symptom severity ( 29771307) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: CEBPA GOLM1 LSM2 LSM3 NTAQ1	39 interacting genes: BANP CBX8 CEBPA CRMP1 DNAAF11 DNAJA1 ERG28 EXOSC10 GBP2 KRT13 LGALS7 LGALS7B LNX1 LSM1 LSM12 LSM3 LSM5 LSM6 LSM7 LSM8 LZTS1 MAGEA3 MAGEA6 MEOX2 PATL1 PCM1 PNMA1 RALA REL RSRC1 SF3B2 SMN1 SNRPD2 SNRPE TEX11 TLE5 TRIM54 ZBTB16 ZNF408
Entrez ID		124801	57819
HPRD ID		08701	06282
Ensembl ID		ENSG00000161654	ENSG00000204392
Uniprot IDs		K7ELG9 Q3MHD2	Q9Y333
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Lsm1-7-Pat1 Complex Lsm2-8 Complex U6 SnRNP Precatalytic Spliceosome U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding P-body Catalytic Step 2 Spliceosome Protein-N-terminal Glutamine Amidohydrolase Activity Response To Vitamin B2 C/EBP Complex U6 SnRNA 3'-end Binding Protein-N-terminal Asparagine Amidohydrolase Activity CHOP-C/EBP Complex White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing, Via Transesterification Reactions Response To Phenylpropanoid Fat Cell Proliferation Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding RNA Metabolic Process Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway STAT Family Protein Binding Osteoblast Development Ribonucleoprotein Complex P-body Assembly RNA Splicing Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides U6 SnRNA Binding Spliceosomal Tri-snRNP Complex Assembly MRNA Processing Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Epithelial Cell Maturation	U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Lsm2-8 Complex U4/U6 X U5 Tri-snRNP Complex U6 SnRNP Lsm1-7-Pat1 Complex RNA Splicing MRNA Metabolic Process MRNA Splicing, Via Spliceosome Precatalytic Spliceosome MRNA Processing Spliceosomal Complex RNA Processing U12-type Spliceosomal Complex MRNA Catabolic Process RNA Metabolic Process Catalytic Step 2 Spliceosome Ribonucleoprotein Complex RNA Binding Spliceosomal Complex Assembly RNA Catabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Nucleobase-containing Compound Metabolic Process P-body PICln-Sm Protein Complex Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Catabolic Process Spliceosomal SnRNP Assembly 7-methylguanosine Cap Hypermethylation U4 SnRNP Methylosome Nuclear Speck Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA U6 SnRNA Binding Histone MRNA Catabolic Process P-body Assembly Negative Regulation Of Metabolic Process MRNA Methylguanosine-cap Decapping Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression U1 SnRNP U5 SnRNP RNA Decapping Protein Binding
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