SPATA2L and GPR37

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SPATA2L	GPR37
Description		spermatogenesis associated 2 like	G protein-coupled receptor 37
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process		Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31015462) Hemoglobin levels ( 32327693) Mean corpuscular volume ( 27863252)	Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 26237428 32341527) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: GPR37 GRB2 NCK2	51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11
Entrez ID		124044	2861
HPRD ID		14515	03992
Ensembl ID		ENSG00000158792	ENSG00000170775
Uniprot IDs		Q8IUW3	O15354
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Vesicle Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Polymerization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Guanyl-nucleotide Exchange Factor Adaptor Activity Regulation Of Actin Filament Length Prosaposin Receptor Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Grb2-EGFR Complex Positive Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Positive Regulation Of T Cell Activation Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Cellular Response To Stress Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Dopamine Metabolic Process Locomotion Involved In Locomotory Behavior Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Actin Cytoskeleton Organization T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of Translation In Response To Stress Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Intracellular Signal Transduction Dopamine Biosynthetic Process Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Actin Filament-based Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Supramolecular Fiber Organization Signal Complex Assembly Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Protein-containing Complex Assembly Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Activation Negative Regulation Of PERK-mediated Unfolded Protein Response Insulin Receptor Substrate Binding Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cell Adhesion Regulation Of Cytoskeleton Organization	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion
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