PLEKHB1 and GNGT1

Number of citations of the paper that reports this interaction (PMID 10585447)
2

Data Source:
HPRD (in vitro)

		PLEKHB1	GNGT1
Gene Name		pleckstrin homology domain containing, family B (evectins) member 1	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Membrane	Photoreceptor Inner Segment Heterotrimeric G-protein Complex Plasma Membrane Photoreceptor Disc Membrane
	Molecular Function	Signal Transducer Activity Protein Binding Protein C-terminus Binding Protein Homodimerization Activity	GTPase Activity Signal Transducer Activity
	Biological Process	Multicellular Organismal Development Phototransduction Regulation Of Cell Differentiation	Signal Transduction Synaptic Transmission Phototransduction, Visible Light Protein Localization Metabolic Process Cardiac Muscle Cell Apoptotic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Eye Photoreceptor Cell Development Cellular Response To Hypoxia
Pathways			Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Activation of GABAB receptors G alpha (s) signalling events Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Olfactory Signaling Pathway Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G beta:gamma signalling through PI3Kgamma The phototransduction cascade G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Visual phototransduction Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ACVR1 ATXN1 BMPR1B GNGT1 RAP1GDS1 SMAD1 TGFBR1 ZDHHC17	10 interactors: GNAS GNB1 GNB2 GNB4 GNB5 IKBKG NAGA PLEKHB1 RHO ZNF277
Entrez ID		58473	2792
HPRD ID		09630	01805
Ensembl ID		ENSG00000021300	ENSG00000127928
Uniprot IDs		Q9UF11	P63211
PDB IDs
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction By Phosphorylation Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Cartilage Development Positive Regulation Of Ossification Regulation Of Signaling Regulation Of Osteoblast Differentiation Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Pharyngeal System Development Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Ossification Regulation Of Extrinsic Apoptotic Signaling Pathway Gamete Generation Activin Receptor Signaling Pathway Positive Regulation Of Cartilage Development Sexual Reproduction Positive Regulation Of Bone Mineralization Multicellular Organismal Reproductive Process Organ Development Positive Regulation Of Biomineral Tissue Development Multicellular Organism Reproduction Cell Fate Commitment Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Organ Morphogenesis Urogenital System Development Reproduction Eye Development Regulation Of Bone Mineralization Signaling Inflammatory Response Cell Communication Mesoderm Formation Endocardial Cushion Cell Fate Commitment Mesoderm Morphogenesis Single Organism Reproductive Process Anatomical Structure Morphogenesis Positive Regulation Of Signal Transduction Heart Development Reproductive Process Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Cellular Response To Glucagon Stimulus Response To Glucagon Phototransduction Detection Of Light Stimulus Regulation Of Rhodopsin Mediated Signaling Pathway Energy Reserve Metabolic Process Rhodopsin Mediated Signaling Pathway Detection Of Abiotic Stimulus Phototransduction, Visible Light Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Detection Of Visible Light Cellular Response To Peptide Cellular Response To Light Stimulus Response To Light Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Generation Of Precursor Metabolites And Energy Cellular Response To Radiation Response To Radiation Response To Peptide Hormone Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Detection Of Stimulus Cellular Response To Hormone Stimulus Cellular Response To Stimulus Dopamine Receptor Signaling Pathway Cellular Response To Fatty Acid Signal Transduction Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Organonitrogen Compound Signaling Cell Communication Response To Fatty Acid Response To Hormone Post-embryonic Body Morphogenesis Red, Far-red Light Phototransduction Response To External Stimulus Response To Stimulus Cell Surface Receptor Signaling Pathway Response To Abiotic Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Retina Development In Camera-type Eye
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